Nominally identical microplastic models differ greatly in their particle-cell interactions.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 Jan 2024
31 Jan 2024
Historique:
received:
01
07
2022
accepted:
19
01
2024
medline:
1
2
2024
pubmed:
1
2
2024
entrez:
31
1
2024
Statut:
epublish
Résumé
Due to the abundance of microplastics in the environment, research about its possible adverse effects is increasing exponentially. Most studies investigating the effect of microplastics on cells still rely on commercially available polystyrene microspheres. However, the choice of these model microplastic particles can affect the outcome of the studies, as even nominally identical model microplastics may interact differently with cells due to different surface properties such as the surface charge. Here, we show that nominally identical polystyrene microspheres from eight different manufacturers significantly differ in their ζ-potential, which is the electrical potential of a particle in a medium at its slipping plane. The ζ-potential of the polystyrene particles is additionally altered after environmental exposure. We developed a microfluidic microscopy platform to demonstrate that the ζ-potential determines particle-cell adhesion strength. Furthermore, we find that due to this effect, the ζ-potential also strongly determines the internalization of the microplastic particles into cells. Therefore, the ζ-potential can act as a proxy of microplastic-cell interactions and may govern adverse effects reported in various organisms exposed to microplastics.
Identifiants
pubmed: 38297000
doi: 10.1038/s41467-024-45281-4
pii: 10.1038/s41467-024-45281-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
922Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 391977956 - SFB 1357
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : INST 91/427-1 FUGG
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 391977956 - SFB 1357
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : OB362/4-1
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 965367 (PlasticsFatE)
Informations de copyright
© 2024. The Author(s).
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