Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 Jan 2024
31 Jan 2024
Historique:
received:
16
03
2023
accepted:
18
01
2024
medline:
1
2
2024
pubmed:
1
2
2024
entrez:
31
1
2024
Statut:
epublish
Résumé
Patients with drug-resistant essential tremor (ET) may undergo Gamma Knife stereotactic radiosurgical thalamotomy (SRS-T), where the ventro-intermediate nucleus of the thalamus (Vim) is lesioned by focused beams of gamma radiations to induce clinical improvement. Here, we studied SRS-T impacts on left Vim dynamic functional connectivity (dFC, n = 23 ET patients scanned before and 1 year after intervention), and on surface-based morphometric brain features (n = 34 patients, including those from dFC analysis). In matched healthy controls (HCs), three dFC states were extracted from resting-state functional MRI data. In ET patients, state 1 spatial stability increased upon SRS-T (F
Identifiants
pubmed: 38297028
doi: 10.1038/s41598-024-52410-y
pii: 10.1038/s41598-024-52410-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2605Subventions
Organisme : Université de Lausanne
ID : Jeune Chercheur en Recherche Clinique
Informations de copyright
© 2024. The Author(s).
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