The impact of paternal age on cumulative assisted reproductive technology outcomes.

To investigate the impact of paternal age on cumulative live birth rate in ART. Retrospective single-center cohort study. All female patients aged 18-43 years and male patients aged 18-60 years, who performed their first ART cycle between January 2018 and December 2020, were included. The primary outcome, cumulative live birth rate (cLBR), was estimated following fresh or frozen embryo transfers issued from an ART cycle. Secondary outcomes included the cumulative pregnancy rate (cPR) and miscarriage rate. Subgroup analyzes were performed as follows: men <45 and ≥ 45; female <35, 35-38, and > 38 years. A total of 2,358 couples were included in this study. The sperm quantity of male patients within both age groups was divided in two groups: normal and abnormal, which were found to be in significantly equal proportions. There were significantly fewer current smokers in the male group ≥45. The cPR was 0.5301 in the group <45 and 0.3111 in the group ≥45, with a According to the results from our study, male age ≥ 45 has a significant impact on cumulative ART outcomes.

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Copyright © 2024 Farabet, Pirtea, Benammar, De Ziegler, Marchiori, Vallée and Ayoubi.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.