Comprehensive characterization of polyproline tri-helix macrocyclic nanoscaffolds for predictive ligand positioning.

Journal

Nanoscale advances
ISSN: 2516-0230
Titre abrégé: Nanoscale Adv
Pays: England
ID NLM: 101738708

Informations de publication

Date de publication:
30 Jan 2024
Historique:
received: 31 10 2023
accepted: 25 12 2023
medline: 1 2 2024
pubmed: 1 2 2024
entrez: 1 2 2024
Statut: epublish

Résumé

Multivalent ligands hold promise for enhancing avidity and selectivity to simultaneously target multimeric proteins, as well as potentially modulating receptor signaling in pharmaceutical applications. Essential for these manipulations are nanosized scaffolds that precisely control ligand display patterns, which can be achieved by using polyproline oligo-helix macrocyclic nanoscaffolds

Identifiants

DOI: 10.1039/d3na00945a PMID: 38298598 PMC: PMC10825903
pubmed: 38298598
doi: 10.1039/d3na00945a
pii: d3na00945a
pmc: PMC10825903
doi:

Types de publication

Journal Article

Langues

eng

Pagination

947-959

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

There are no conflicts to declare.

Auteurs

Chia-Lung Tsai (CL)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.

Je-Wei Chang (JW)

National Synchrotron Radiation Research Center Hsinchu 300092 Taiwan usjeng@nsrrc.org.tw.

Kum-Yi Cheng (KY)

Department of Chemistry and Centre for Emerging Materials and Advanced Devices, National Taiwan University Taipei 106319 Taiwan chhchen@ntu.edu.tw.

Yu-Jing Lan (YJ)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
ORCID: 0000-0002-5971-5284

Yi-Cheng Hsu (YC)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.

Qun-Da Lin (QD)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.

Tzu-Yuan Chen (TY)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.

Orion Shih (O)

National Synchrotron Radiation Research Center Hsinchu 300092 Taiwan usjeng@nsrrc.org.tw.

Chih-Hsun Lin (CH)

Department of Chemistry and Centre for Emerging Materials and Advanced Devices, National Taiwan University Taipei 106319 Taiwan chhchen@ntu.edu.tw.

Po-Hsun Chiang (PH)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.

Mantas Simenas (M)

Faculty of Physics, Vilnius University Sauletekio 3 LT-10257 Vilnius Lithuania.
ORCID: 0000-0002-2733-2270

Vidmantas Kalendra (V)

Faculty of Physics, Vilnius University Sauletekio 3 LT-10257 Vilnius Lithuania.

Yun-Wei Chiang (YW)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
ORCID: 0000-0002-2101-8918

Chun-Hsien Chen (CH)

Department of Chemistry and Centre for Emerging Materials and Advanced Devices, National Taiwan University Taipei 106319 Taiwan chhchen@ntu.edu.tw.
ORCID: 0000-0001-5507-3248

U-Ser Jeng (US)

National Synchrotron Radiation Research Center Hsinchu 300092 Taiwan usjeng@nsrrc.org.tw.
Department of Chemical Engineering, National Tsing Hua University Hsinchu 300044 Taiwan.
College of Semiconductor Research, National Tsing Hua University Hsinchu 300044 Taiwan.
ORCID: 0000-0002-2247-5061

Sheng-Kai Wang (SK)

Department of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University Hsinchu 300044 Taiwan.
ORCID: 0000-0002-3827-7983

Classifications MeSH