Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury.

Prevention or treatment for acoustic injury has been met with many translational challenges, resulting in the absence of FDA-approved interventions. Localized hypothermia following noise exposure mitigates acute cochlear injury and may serve as a potential avenue for therapeutic approaches. However, the mechanisms by which hypothermia results in therapeutic improvements are poorly understood. This study performs the transcriptomic analysis of cochleae from juvenile rats that experienced noise-induced hearing loss (NIHL) followed by hypothermia or control normothermia treatment. Differential gene expression results from RNA sequencing at 24 h post-exposure to noise suggest that NIHL alone results in increased inflammatory and immune defense responses, involving complement activation and cytokine-mediated signaling. Hypothermia treatment post-noise, in turn, may mitigate the acute inflammatory response. This study provides a framework for future research to optimize hypothermic intervention for ameliorating hearing loss and suggests additional pathways that could be targeted for NIHL therapeutic intervention.

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Copyright © 2024 Rincon Sabatino, Sangaletti, Griswold, Dietrich, King and Rajguru.

Déclaration de conflit d'intérêts

SRa and CK are inventors of the intellectual property used in this study. SRa and the University of Miami may receive royalties for the commercialization of the IP. SRa and CK are co-founders of RestorEar Devices LLC. RestorEar did not provide any financial support for the work described in this manuscript. All conflict of interests are disclosed to and managed by the University of Miami. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.