Cell lineage-guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer.

Spemann–Mangold Organizer Xenopus mass spectrometry metabolomics proteomics

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
06 Feb 2024
Historique:
medline: 1 2 2024
pubmed: 1 2 2024
entrez: 1 2 2024
Statut: ppublish

Résumé

Molecular understanding of the vertebrate Organizer, a tissue center critical for inductive signaling during gastrulation, has so far been mostly limited to transcripts and a few proteins, the latter due to limitations in detection and sensitivity. The Spemann-Mangold Organizer (SMO) in the South African Clawed Frog (

Identifiants

DOI: 10.1073/pnas.2311625121 PMID: 38300871
pubmed: 38300871
doi: 10.1073/pnas.2311625121
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2311625121

Subventions

Organisme : HHS | National Institutes of Health (NIH)
ID : 1R35GM124755

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Aparna B Baxi (AB)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
Department of Anatomy and Cell Biology, School of Medical and Health Sciences, The George Washington University, Washington, DC 20037.

Jie Li (J)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
ORCID: 0000-0002-4282-4919

Vi M Quach (VM)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.

Leena R Pade (LR)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.

Sally A Moody (SA)

Department of Anatomy and Cell Biology, School of Medical and Health Sciences, The George Washington University, Washington, DC 20037.
ORCID: 0000-0003-4192-1087

Peter Nemes (P)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
Department of Anatomy and Cell Biology, School of Medical and Health Sciences, The George Washington University, Washington, DC 20037.
ORCID: 0000-0002-4704-4997

Classifications MeSH