Resting state functional connectivity in dependent cannabis users: The moderating role of cannabis attitudes.

Benefits Cannabis attitudes Cannabis use Cross-cultural Cultural neuroscience Harms

Journal

Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587

Informations de publication

Date de publication:
15 Jan 2024
Historique:
received: 24 05 2023
revised: 04 12 2023
accepted: 08 01 2024
medline: 2 2 2024
pubmed: 2 2 2024
entrez: 1 2 2024
Statut: aheadofprint

Résumé

The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which has been associated with cannabis use initiation and persistent use. However, it is unclear how cannabis attitudes might affect the brain processes underlying cannabis use. Resting state functional connectivity (RSFC) within and between the executive control network (ECN), salience network (SN), and default mode network (DMN) was assessed in 110 near-daily cannabis users with cannabis use disorder (CUD) and 79 controls from The Netherlands and Texas, USA. Participants completed a questionnaire assessing the perceived benefits and harms of cannabis use from their personal, friends-family's, and country-state's perspectives and reported on their cannabis use (gram/week), CUD severity, and cannabis-related problems. RSFC within the dorsal SN was lower in cannabis users than controls, while no group differences in between-network RSFC were observed. Furthermore, heavier cannabis use was associated with lower dorsal SN RSFC in the cannabis group. Perceived benefits and harms of cannabis - from personal, friends-family's, and country-state's perspectives - moderated associations of cannabis use, CUD severity, and cannabis use-related problems with within-network RSFC of the SN, ECN, and DMN. Personal perceived benefits and country-state perceived harms moderated the association between CUD severity and RSFC between the ventral and dorsal DMN. This study highlights the importance of considering individual differences in the perceived harms and benefits of cannabis use as a factor in the associations between brain functioning and cannabis use, CUD severity, and cannabis use-related problems.

Sections du résumé

BACKGROUND BACKGROUND
The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which has been associated with cannabis use initiation and persistent use. However, it is unclear how cannabis attitudes might affect the brain processes underlying cannabis use.
METHODS METHODS
Resting state functional connectivity (RSFC) within and between the executive control network (ECN), salience network (SN), and default mode network (DMN) was assessed in 110 near-daily cannabis users with cannabis use disorder (CUD) and 79 controls from The Netherlands and Texas, USA. Participants completed a questionnaire assessing the perceived benefits and harms of cannabis use from their personal, friends-family's, and country-state's perspectives and reported on their cannabis use (gram/week), CUD severity, and cannabis-related problems.
RESULTS RESULTS
RSFC within the dorsal SN was lower in cannabis users than controls, while no group differences in between-network RSFC were observed. Furthermore, heavier cannabis use was associated with lower dorsal SN RSFC in the cannabis group. Perceived benefits and harms of cannabis - from personal, friends-family's, and country-state's perspectives - moderated associations of cannabis use, CUD severity, and cannabis use-related problems with within-network RSFC of the SN, ECN, and DMN. Personal perceived benefits and country-state perceived harms moderated the association between CUD severity and RSFC between the ventral and dorsal DMN.
CONCLUSIONS CONCLUSIONS
This study highlights the importance of considering individual differences in the perceived harms and benefits of cannabis use as a factor in the associations between brain functioning and cannabis use, CUD severity, and cannabis use-related problems.

Identifiants

DOI: 10.1016/j.drugalcdep.2024.111090 PMID: 38301388
pubmed: 38301388
pii: S0376-8716(24)00011-5
doi: 10.1016/j.drugalcdep.2024.111090
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111090

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest none.

Auteurs

E Kroon (E)

Neuroscience of Addiction Lab, Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, the Netherlands; Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: emesekroon@gmail.com.

Y J Toenders (YJ)

Developmental and Educational Psychology, Leiden University, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, the Netherlands; Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, the Netherlands.

L N Kuhns (LN)

Neuroscience of Addiction Lab, Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, the Netherlands; Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

J Cousijn (J)

Neuroscience of Addiction Lab, Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, the Netherlands; Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

F Filbey (F)

School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.

Classifications MeSH