Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer.
Allergy and immunology
Appendectomy
Appendix
Colorectal neoplasms
Gastrointestinal microbiome
Journal
Journal of gastroenterology and hepatology
ISSN: 1440-1746
Titre abrégé: J Gastroenterol Hepatol
Pays: Australia
ID NLM: 8607909
Informations de publication
Date de publication:
01 Feb 2024
01 Feb 2024
Historique:
revised:
11
12
2023
received:
24
10
2023
accepted:
07
01
2024
medline:
2
2
2024
pubmed:
2
2
2024
entrez:
2
2
2024
Statut:
aheadofprint
Résumé
The role of appendectomy in the pathogenesis of colorectal cancer (CRC) is a recent topic of contention. Given that appendectomy remains one of the most commonly performed operations and a first-line management strategy of acute appendicitis, it is inherently crucial to elucidate the association between prior appendectomy and subsequent development of CRC, as there may be long-term health repercussions. In this review, we summarize the data behind the relationship of CRC in post-appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix. We seek to piece together the current landscape surrounding the microbiome and immunological changes in the colon post-appendectomy and suggest a direction for future research involving molecular, transcriptomic, and immunologic analysis to complement our current understanding of the alterations in gut microbiome.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NTU Start Up Grant
ID : 021281-00001
Organisme : NTU Start Up Grant
ID : 021337-00001
Organisme : Centre for Microbiome Medicine
Organisme : Wang Lee Wah Memorial Fund
Organisme : Singapore Ministry of Education (MOE) Tier 1 Academic Research Fund
ID : RG37/22
Organisme : Singapore National Medical Research Council Clinician Scientist Individual Research Grant
ID : CIRG23jan-0004
Organisme : Singapore National Supercomputing Centre
ID : 12002587
Organisme : Singapore National Supercomputing Centre
ID : 12003632
Informations de copyright
© 2024 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
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