Naturalistic symptom trajectories of atypical anorexia nervosa, anorexia nervosa, and bulimia nervosa in a prospective cohort study of United States college students.
anorexia nervosa
atypical anorexia nervosa
bulimia nervosa
college mental health
natural course
symptom trajectories
Journal
The International journal of eating disorders
ISSN: 1098-108X
Titre abrégé: Int J Eat Disord
Pays: United States
ID NLM: 8111226
Informations de publication
Date de publication:
02 Feb 2024
02 Feb 2024
Historique:
revised:
15
01
2024
received:
16
09
2023
accepted:
18
01
2024
medline:
2
2
2024
pubmed:
2
2
2024
entrez:
2
2
2024
Statut:
aheadofprint
Résumé
Research on the natural course of symptoms of atypical anorexia nervosa (AN) relative to AN and bulimia nervosa (BN) is limited yet needed to inform nosology and improve understanding of atypical AN. This study aimed to 1) characterize trajectories of eating disorder and internalizing (anxiety, depression) symptoms in college students with and without a history of atypical AN, AN, and BN; and 2) compare sex and race/ethnicity distributions across groups. United States college students who participated in Spit for Science™, a prospective cohort study, were classified as having a history of atypical AN (n = 125), AN (n = 160), BN (n = 617), or as non-eating-disorder controls (NCs, n = 5876). Generalized and linear mixed-effects models assessed group differences in eating and internalizing symptom trajectories, and logistic regression compared groups on sex and race/ethnicity distributions. Atypical AN participants demonstrated elevated eating disorder and internalizing symptoms compared to NCs during college, but less severe symptoms than AN and BN participants. Although all eating disorder groups showed signs of improvement in fasting and driven exercise, purging and depression remained elevated. Atypical AN participants showed increasing anxiety and stable binge-eating trajectories compared to AN and/or BN participants. The atypical AN group comprised significantly more people of color than the AN group. Findings underscore that atypical AN is a severe psychiatric disorder. As atypical AN may present as less severe than AN and BN and disproportionately affects people of color, clinicians should be mindful of biases that could delay diagnosis and care. College students with histories of atypical AN, AN, and BN demonstrated improvements in fasting and driven exercise and stable purging and depression levels. Atypical AN students showed worsening anxiety and stable binge-eating trajectories compared to favorable changes among AN and BN students. A higher percentage of atypical AN (vs. AN) students were people of color. Findings may improve the detection of atypical AN in college students.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAAA NIH HHS
ID : K01AA024152
Pays : United States
Organisme : NIAAA NIH HHS
ID : K02AA018755
Pays : United States
Organisme : NIAAA NIH HHS
ID : P20AA017828
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50AA022537
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37AA011408
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1RR031990
Pays : United States
Organisme : NCATS NIH HHS
ID : UM1TR004360
Pays : United States
Investigateurs
Karen Chartier
(K)
Ananda Amstadter
(A)
Danielle M Dick
(DM)
Emily Lilley
(E)
Renolda Gelzinis
(R)
Anne Morris
(A)
Katie Bountress
(K)
Amy E Adkins
(AE)
Nathaniel Thomas
(N)
Zoe Neale
(Z)
Kimberly Pedersen
(K)
Thomas Bannard
(T)
Seung B Cho
(SB)
Kimberly Pedersen
(K)
Amy E Adkins
(AE)
Peter Barr
(P)
Holly Byers
(H)
Erin C Berenz
(EC)
Erin Caraway
(E)
Seung B Cho
(SB)
James S Clifford
(JS)
Megan Cooke
(M)
Elizabeth Do
(E)
Alexis C Edwards
(AC)
Neeru Goyal
(N)
Laura M Hack
(LM)
Lisa J Halberstadt
(LJ)
Sage Hawn
(S)
Sally Kuo
(S)
Emily Lasko
(E)
Jennifer Lend
(J)
Mackenzie Lind
(M)
Elizabeth Long
(E)
Alexandra Martelli
(A)
Jacquelyn L Meyers
(JL)
Kerry Mitchell
(K)
Ashlee Moore
(A)
Arden Moscati
(A)
Aashir Nasim
(A)
Zoe Neale
(Z)
Jill Opalesky
(J)
Cassie Overstreet
(C)
A Christian Pais
(AC)
Tarah Raldiris
(T)
Jessica Salvatore
(J)
Jeanne Savage
(J)
Rebecca Smith
(R)
David Sosnowski
(D)
Jinni Su
(J)
Nathaniel Thomas
(N)
Chloe Walker
(C)
Marcie Walsh
(M)
Teresa Willoughby
(T)
Madison Woodroof
(M)
Jia Yan
(J)
Cuie Sun
(C)
Brandon Wormley
(B)
Brien Riley
(B)
Fazil Aliev
(F)
Roseann E Peterson
(RE)
Bradley T Webb
(BT)
Informations de copyright
© 2024 Wiley Periodicals LLC.
Références
Ackard, D. M., Fulkerson, J. A., & Neumark-Sztainer, D. (2011). Stability of eating disorder diagnostic classifications in adolescents: Five-year longitudinal findings from a population-based study. Eating Disorders, 19(4), 308-322. https://doi.org/10.1080/10640266.2011.584804
APA. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). APA.
APA. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub.
Breithaupt, L., Kahn, D. L., Slattery, M., Plessow, F., Mancuso, C., Izquierdo, A., Dreier, M. J., Becker, K., Franko, D. L., Thomas, J. J., Holsen, L., Lawson, E. A., Misra, M., & Eddy, K. T. (2022). Eighteen-month course and outcome of adolescent restrictive eating disorders: Persistence, crossover, and recovery. Journal of Clinical Child & Adolescent Psychology, 51(5), 715-725. https://doi.org/10.1080/15374416.2022.2034634
Bruch, H. (1973). Eating disorders: Obesity, anorexia nervosa, and the person within. Basic Books.
Buckner, J. D., Silgado, J., & Lewinsohn, P. M. (2010). Delineation of differential temporal relations between specific eating and anxiety disorders. Journal of Psychiatric Research, 44(12), 781-787. https://doi.org/10.1016/j.jpsychires.2010.01.014
Buuren, S. v., & Groothuis-Oudshoorn, K. (2011). Mice: Multivariate imputation by chained equations in R. Journal of Statistical Software, 45(1), 1-67. https://doi.org/10.18637/jss.v045.i03
CDC. (2022, February 3). Growth chart training resources. Centers for Disease Control and Prevention https://www.cdc.gov/nccdphp/dnpao/growthcharts/training/bmiage/page5_2.html
Chapa, D. A. N., Bohrer, B. K., & Forbush, K. T. (2018). Is the diagnostic threshold for bulimia nervosa clinically meaningful? Eating Behaviors, 28, 16-19. https://doi.org/10.1016/j.eatbeh.2017.12.002
Derogatis, L. R., Lipman, R. S., & Covi, L. (1973). SCL-90: An outpatient psychiatric rating scale-preliminary report. Psychopharmacology Bulletin, 9(1), 13-28.
Dick, D. M., Nasim, A., Edwards, A. C., Salvatore, J. E., Cho, S. B., Adkins, A., Meyers, J., Yan, J., Cooke, M., Clifford, J., Goyal, N., Halberstadt, L., Ailstock, K., Neale, Z., Opalesky, J., Hancock, L., Donovan, K. K., Sun, C., Riley, B., & Kendler, K. S. (2014). Spit for science: Launching a longitudinal study of genetic and environmental influences on substance use and emotional health at a large US university. Frontiers in Genetics, 5, 47. https://doi.org/10.3389/fgene.2014.00047
Eddy, K. T., Tabri, N., Thomas, J. J., Murray, H. B., Keshaviah, A., Hastings, E., Edkins, K., Krishna, M., Herzog, D. B., Keel, P. K., & Franko, D. L. (2017). Recovery from anorexia nervosa and bulimia nervosa at 22-year follow-up. The Journal of Clinical Psychiatry, 78(2), 184-189. https://doi.org/10.4088/JCP.15m10393
Ekeroth, K., Clinton, D., Norring, C., & Birgegård, A. (2013). Clinical characteristics and distinctiveness of DSM-5 eating disorder diagnoses: Findings from a large naturalistic clinical database. Journal of Eating Disorders, 1, 31. https://doi.org/10.1186/2050-2974-1-31
Fairburn, C. G., & Beglin, S. (2008). Eating disorder examination questionnaire (EDE-Q 6.0). In C. G. Fairburn (Ed.), Cognitive behavior therapy and eating disorders (pp. 309-313). Guilford Press.
Falvey, S. E., Hahn, S. L., Anderson, O. S., Lipson, S. K., & Sonneville, K. R. (2021). Diagnosis of eating disorders among college students: A comparison of military and civilian students. Military Medicine, 186(9-10), 975-983. https://doi.org/10.1093/milmed/usab084
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Jr., Winokur, G., & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26(1), 57-63. https://doi.org/10.1001/archpsyc.1972.01750190059011
Forney, K. J., Brown, T. A., Holland-Carter, L. A., Kennedy, G. A., & Keel, P. K. (2017). Defining “significant weight loss” in atypical anorexia nervosa. The International Journal of Eating Disorders, 50(8), 952-962. https://doi.org/10.1002/eat.22717
Glasofer, D. R., Muratore, A. F., Attia, E., Wu, P., Wang, Y., Minkoff, H., Rufin, T., Walsh, B. T., & Steinglass, J. E. (2020). Predictors of illness course and health maintenance following inpatient treatment among patients with anorexia nervosa. Journal of Eating Disorders, 8(1), 69. https://doi.org/10.1186/s40337-020-00348-7
Gordon, K. H., Brattole, M. M., Wingate, L. R., & Joiner, T. E. (2006). The impact of client race on clinician detection of eating disorders. Behavior Therapy, 37(4), 319-325. https://doi.org/10.1016/j.beth.2005.12.002
Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009). Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics, 42(2), 377-381. https://doi.org/10.1016/j.jbi.2008.08.010
Harrop, E. N., Hutcheson, R., Harner, V., Mensinger, J. L., & Lindhorst, T. (2023). “You Don't look anorexic”: Atypical anorexia patient experiences of weight stigma in medical care. Body Image, 46, 48-61. https://doi.org/10.1016/j.bodyim.2023.04.008
Harrop, E. N., Mensinger, J. L., Moore, M., & Lindhorst, T. (2021). Restrictive eating disorders in higher weight persons: A systematic review of atypical anorexia nervosa prevalence and consecutive admission literature. The International Journal of Eating Disorders, 54(8), 1328-1357. https://doi.org/10.1002/eat.23519
Johnson, S. N., Forbush, K. T., Swanson, T. J., & Christensen, K. A. (2021). An empirical evaluation of the diagnostic threshold between full-threshold and sub-threshold bulimia nervosa. Eating Behaviors, 42, 101540. https://doi.org/10.1016/j.eatbeh.2021.101540
Johnson-Munguia, S., Negi, S., Chen, Y., Thomeczek, M. L., & Forbush, K. T. (2023). Eating disorder psychopathology, psychiatric impairment, and symptom frequency of atypical anorexia nervosa versus anorexia nervosa: A systematic review and meta-analysis. The International Journal of Eating Disorders, 1-19. https://doi.org/10.1002/eat.23989
Keski-Rahkonen, A., Raevuori, A., Bulik, C. M., Hoek, H. W., Sihvola, E., Kaprio, J., & Rissanen, A. (2013). Depression and drive for thinness are associated with persistent bulimia nervosa in the community. European Eating Disorders Review, 21(2), 121-129. https://doi.org/10.1002/erv.2182
Kinasz, K., Accurso, E. C., Kass, A. E., & Le Grange, D. (2016). Sex differences in the clinical presentation of eating disorders in youth. The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine, 58(4), 410-416. https://doi.org/10.1016/j.jadohealth.2015.11.005
Lipson, S. K., & Sonneville, K. R. (2017). Eating disorder symptoms among undergraduate and graduate students at 12 U.S. colleges and universities. Eating Behaviors, 24, 81-88. https://doi.org/10.1016/j.eatbeh.2016.12.003
Lloyd, E. C., Haase, A. M., Foster, C. E., & Verplanken, B. (2019). A systematic review of studies probing longitudinal associations between anxiety and anorexia nervosa. Psychiatry Research, 276, 175-185. https://doi.org/10.1016/j.psychres.2019.05.010
Lowe, M. R., Piers, A. D., & Benson, L. (2018). Weight suppression in eating disorders: A research and conceptual update. Current Psychiatry Reports, 20(10), 80. https://doi.org/10.1007/s11920-018-0955-2
Matthews, A., Kramer, R. A., & Mitan, L. (2022). Eating disorder severity and psychological morbidity in adolescents with anorexia nervosa or atypical anorexia nervosa and premorbid overweight/obesity. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 27(1), 233-242. https://doi.org/10.1007/s40519-021-01168-7
McClelland, J., Robinson, L., Potterton, R., Mountford, V., & Schmidt, U. (2020). Symptom trajectories into eating disorders: A systematic review of longitudinal, nonclinical studies in children/adolescents. European Psychiatry, 63(1), e60. https://doi.org/10.1192/j.eurpsy.2020.55
Monteleone, A. M., Pellegrino, F., Croatto, G., Carfagno, M., Hilbert, A., Treasure, J., Wade, T., Bulik, C. M., Zipfel, S., Hay, P., Schmidt, U., Castellini, G., Favaro, A., Fernandez-Aranda, F., Il Shin, J., Voderholzer, U., Ricca, V., Moretti, D., Busatta, D., … Solmi, M. (2022). Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses. Neuroscience and Biobehavioral Reviews, 142, 104857. https://doi.org/10.1016/j.neubiorev.2022.104857
Moreno, R., Buckelew, S. M., Accurso, E. C., & Raymond-Flesch, M. (2023). Disparities in access to eating disorders treatment for publicly-insured youth and youth of color: A retrospective cohort study. Journal of Eating Disorders, 11, 10. https://doi.org/10.1186/s40337-022-00730-7
Phillipou, A., & Beilharz, F. (2019). Should we shed the weight criterion for anorexia nervosa? The Australian and New Zealand Journal of Psychiatry, 53(6), 501-502. https://doi.org/10.1177/0004867418814958
R Core Team. (2022). R: A language and environment for statistical computing (4.2.2) [Computer software]. R Core Team https://www.R-project.org/
Sawyer, S. M., Whitelaw, M., Le Grange, D., Yeo, M., & Hughes, E. K. (2016). Physical and psychological morbidity in adolescents with atypical anorexia nervosa. Pediatrics, 137(4), e20154080. https://doi.org/10.1542/peds.2015-4080
Solmi, M., Radua, J., Olivola, M., Croce, E., Soardo, L., Salazar de Pablo, G., Il Shin, J., Kirkbride, J. B., Jones, P., Kim, J. H., Kim, J. Y., Carvalho, A. F., Seeman, M. V., Correll, C. U., & Fusar-Poli, P. (2022). Age at onset of mental disorders worldwide: Large-scale meta-analysis of 192 epidemiological studies. Molecular Psychiatry, 27(1), 281-295. https://doi.org/10.1038/s41380-021-01161-7
Stice, E., Burton, E. M., & Shaw, H. (2004). Prospective relations between bulimic pathology, depression, and substance abuse: Unpacking comorbidity in adolescent girls. Journal of Consulting and Clinical Psychology, 72(1), 62-71. https://doi.org/10.1037/0022-006X.72.1.62
Stice, E., Marti, C. N., & Rohde, P. (2013). Prevalence, incidence, impairment, and course of the proposed DSM-5 eating disorder diagnoses in an 8-year prospective community study of young women. Journal of Abnormal Psychology, 122(2), 445-457. https://doi.org/10.1037/a0030679
Stice, E., Rohde, P., Shaw, H., & Desjardins, C. (2020). Weight suppression increases odds for future onset of anorexia nervosa, bulimia nervosa, and purging disorder, but not binge eating disorder. The American Journal of Clinical Nutrition, 112(4), 941-947. https://doi.org/10.1093/ajcn/nqaa146
Strand, M., Zvrskovec, J., Hübel, C., Peat, C. M., Bulik, C. M., & Birgegård, A. (2020). Identifying research priorities for the study of atypical anorexia nervosa: A Delphi study. International Journal of Eating Disorders, 53(10), 1729-1738. https://doi.org/10.1002/eat.23358
Trafford, A. M., Carr, M. J., Ashcroft, D. M., Chew-Graham, C. A., Cockcroft, E., Cybulski, L., Garavini, E., Garg, S., Kabir, T., Kapur, N., Temple, R. K., Webb, R. T., & Mok, P. L. H. (2023). Temporal trends in eating disorder and self-harm incidence rates among adolescents and young adults in the UK in the 2 years since onset of the COVID-19 pandemic: A population-based study. The Lancet Child & Adolescent Health, 7(8), 544-554. https://doi.org/10.1016/S2352-4642(23)00126-8
Walsh, B. T., Hagan, K. E., & Lockwood, C. (2023). A systematic review comparing atypical anorexia nervosa and anorexia nervosa. The International Journal of Eating Disorders, 56(4), 798-820. https://doi.org/10.1002/eat.23856
Whitelaw, M., Gilbertson, H., Lee, K. J., & Sawyer, S. M. (2014). Restrictive eating disorders among adolescent inpatients. Pediatrics, 134(3), e758-e764. https://doi.org/10.1542/peds.2014-0070
Zerwas, S., Lund, B. C., Von Holle, A., Thornton, L. M., Berrettini, W. H., Brandt, H., Crawford, S., Fichter, M. M., Halmi, K. A., Johnson, C., Kaplan, A. S., La Via, M., Mitchell, J., Rotondo, A., Strober, M., Woodside, D. B., Kaye, W. H., & Bulik, C. M. (2013). Factors associated with recovery from anorexia nervosa. Journal of Psychiatric Research, 47(7), 972-979. https://doi.org/10.1016/j.jpsychires.2013.02.011