Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING.
STING
activin
cancer
intercellular communication
interferon
knockdown
profiling
scRNA-seq
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
11
2023
accepted:
22
12
2023
medline:
2
2
2024
pubmed:
2
2
2024
entrez:
2
2
2024
Statut:
epublish
Résumé
The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly impedes CD8
Identifiants
pubmed: 38304252
doi: 10.3389/fimmu.2023.1335207
pmc: PMC10830842
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1335207Informations de copyright
Copyright © 2024 Pinjusic, Ambrosini, Lourenco, Fournier, Iseli, Guex, Egorova, Nassiri and Constam.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.