Probing Molecular Packing of Lipid Nanoparticles from


Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
02 Feb 2024
Historique:
medline: 2 2 2024
pubmed: 2 2 2024
entrez: 2 2 2024
Statut: aheadofprint

Résumé

Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their efficient delivery of oligonucleotide cargo to host cells. Gaining insights into the molecular properties of LNPs is crucial for their effective design and characterization. However, analysis of their internal structure at the molecular level presents a significant challenge. This study introduces

Identifiants

pubmed: 38306310
doi: 10.1021/acs.analchem.3c04430
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Ryan Schroder (R)

Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Phillip J Dorsey (PJ)

Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Joe Vanderburgh (J)

Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Wei Xu (W)

Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Suzanne M D'Addio (SM)

Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Lee Klein (L)

Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Marian Gindy (M)

Small Molecule Science and Technology, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Yongchao Su (Y)

Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Classifications MeSH