Effectiveness of dexmedetomidine during surgery under general anaesthesia on patient-centred outcomes: a systematic review and Bayesian meta-analysis protocol.

Adult anaesthesia CLINICAL PHARMACOLOGY Pain management Patient Reported Outcome Measures Patient-Centered Care SURGERY

Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
01 Feb 2024
Historique:
medline: 3 2 2024
pubmed: 3 2 2024
entrez: 2 2 2024
Statut: epublish

Résumé

Dexmedetomidine is a promising pharmaceutical strategy to minimise opioid use during surgery. Despite its growing use, it is uncertain whether dexmedetomidine can improve patient-centred outcomes such as quality of recovery and pain. We will conduct a systematic review and meta-analysis following the recommendations of the Our systematic review does not require research ethics approval. It will help inform current clinical practice guidelines and guide development of future randomised controlled trials. The results will be disseminated in open-access peer-reviewed journals, presented at conferences and shared among collaborators and networks. CRD42023439896.

Identifiants

DOI: 10.1136/bmjopen-2023-080012 PMID: 38307526
pubmed: 38307526
pii: bmjopen-2023-080012
doi: 10.1136/bmjopen-2023-080012
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e080012

Informations de copyright

© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: IG has received consulting fees from GW Research, Eupraxia, Biogen and Novaremed.

Auteurs

Michael Verret (M)

Departments of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Université Laval, Québec, Quebec, Canada Michael.verret.med@ssss.gouv.qc.ca.
Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), CHU de Québec - Université Laval Research Center, Québec, Quebec, Canada.
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
ORCID: 0000-0003-3257-7878

John Bao Phuc Le (JBP)

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Manoj M Lalu (MM)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
ORCID: 0000-0002-0322-382X

Daniel I McIsaac (DI)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
ORCID: 0000-0002-8543-1859

Stuart Nicholls (S)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Alexis F Turgeon (AF)

Departments of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Université Laval, Québec, Quebec, Canada.
Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), CHU de Québec - Université Laval Research Center, Québec, Quebec, Canada.
ORCID: 0000-0001-5675-8791

Brian Hutton (B)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
ORCID: 0000-0001-5662-8647

Fiona Zivkovic (F)

Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada.

Megan Graham (M)

Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada.

Maxime Le (M)

Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada.

Allison Geist (A)

Patient Partner, The Ottawa Hospital, Ottawa, Ontario, Canada.

Melanie Berube (M)

Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), CHU de Québec - Université Laval Research Center, Québec, Quebec, Canada.
Faculty of Nursing, Université Laval, Québec, Quebec, Canada.
ORCID: 0000-0002-6657-3915

Ian Gilron (I)

Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
ORCID: 0000-0002-5293-8792

Patricia Poulin (P)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Helena Daudt (H)

Pain Canada, Pain BC, Vancouver, Alberta, Canada.

Guillaume Martel (G)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Department of Surgery, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
ORCID: 0000-0002-1242-2601

Jason McVicar (J)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.

Husein Moloo (H)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Department of Surgery, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Dean A Fergusson (DA)

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Department of Surgery, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
ORCID: 0000-0002-3389-2485

Classifications MeSH