A Bioengineered Nanovesicle Vaccine Boosts T-B cell Interaction for Immunotherapy of Echinococcus multilocularis.
Alveolar echinococcosis
T/B cells collaboration
nanovaccine
nanovesicle
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
22 Mar 2024
22 Mar 2024
Historique:
received:
17
12
2023
pubmed:
3
2
2024
medline:
3
2
2024
entrez:
2
2
2024
Statut:
ppublish
Résumé
Alveolar echinococcosis (AE) is a zoonotic parasitic disease, resulting from being infected with the metacestode larvae of the tapeworm Echinococcus multilocularis (E. multilocularis). Novel prophylactic and therapeutic interventions are urgently needed since the current chemotherapy displays limited efficiency in AE treatment. Bioengineered nano cellular membrane vesicles are widely used for displaying the native conformational epitope peptides because of their unique structure and biocompatibility. In this study, four T-cells and four B-cells dominant epitope peptides of E. multilocularis with high immunogenicity were engineered into the Vero cell surface to construct a membrane vesicle nanovaccine for the treatment of AE. The results showed that the nanovesicle vaccine can efficiently activate dendritic cells, induce specific T/B cells to form a mutually activated circuit, and inhibit E. multilocularis infection. This study presents for the first time a nanovaccine strategy that can completely eliminate the burden of E. multilocularis.
Identifiants
pubmed: 38308123
doi: 10.1002/anie.202319489
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202319489Subventions
Organisme : National Natural Science Foundation of China
ID : 81925019, U22A20333, 82272144, 82272365
Organisme : Major State Basic Research Development Program of China
ID : 2023YFB3810000
Organisme : Shenzhen Science and Technology Innovation Commission
ID : JCYJ20220530143411025, JCYJ20230807091404010, B2302014
Organisme : National Parasitic Resources Center-the Ministry of Science and Technology fund
ID : NPRC-2019-194-30
Informations de copyright
© 2024 Wiley-VCH GmbH.
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