Comparative Analysis of PEG-Free and PEG-Based Self-Emulsifying Drug Delivery Systems for Enhanced Oral Bioavailability of Therapeutic (Poly) Peptides.

Diabetes Hydrophobic ion pairing Insulin Lipid-based formulation oral peptide delivery

Journal

Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338

Informations de publication

Date de publication:
02 Feb 2024
Historique:
revised: 13 01 2024
received: 31 08 2023
medline: 3 2 2024
pubmed: 3 2 2024
entrez: 3 2 2024
Statut: aheadofprint

Résumé

This study aims to compare the potential of Polyethylene glycol (PEG-free and PEG-based self-emulsifying drug delivery systems (SEDDS) for the oral administration of insulin glargine (IG). Hydrophobic ion pairs (HIPs) of IG are formed using various counterions. HIPs are assessed for log P

Identifiants

pubmed: 38308358
doi: 10.1002/smll.202307618
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2307618

Subventions

Organisme : FWF
ID : P 30839-B30

Informations de copyright

© 2024 The Authors. Small published by Wiley-VCH GmbH.

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Auteurs

Soheil Haddadzadegan (S)

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Dennis To (D)

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Arne Matteo Jörgensen (A)

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Richard Wibel (R)

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Flavia Laffleur (F)

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Andreas Bernkop-Schnürch (A)

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria.

Classifications MeSH