Imaging the Vesicular Acetylcholine Transporter in Schizophrenia: a PET study using [
[(18)F]-VAT positron emission tomography (PET)
acetylcholine
neuroimaging
psychosis
schizophrenia
vesicular acetylcholine transporter (VAChT)
working memory or cognitive impairment
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
01 Feb 2024
01 Feb 2024
Historique:
received:
07
09
2023
revised:
10
01
2024
accepted:
23
01
2024
medline:
4
2
2024
pubmed:
4
2
2024
entrez:
3
2
2024
Statut:
aheadofprint
Résumé
Despite longstanding interest in the central cholinergic system in schizophrenia, cholinergic imaging studies in patients have been limited to receptors. Here, we conducted a proof-of-concept positron emission tomography (PET) study using [ Eighteen adults with schizophrenia or schizoaffective disorder (SCZ) and 14 healthy controls underwent PET scan with [ No group differences in [ In this initial study, severity of two important features of schizophrenia-psychosis and working memory deficit-were strongly associated with [
Sections du résumé
BACKGROUND
BACKGROUND
Despite longstanding interest in the central cholinergic system in schizophrenia, cholinergic imaging studies in patients have been limited to receptors. Here, we conducted a proof-of-concept positron emission tomography (PET) study using [
METHODS
METHODS
Eighteen adults with schizophrenia or schizoaffective disorder (SCZ) and 14 healthy controls underwent PET scan with [
RESULTS
RESULTS
No group differences in [
CONCLUSION
CONCLUSIONS
In this initial study, severity of two important features of schizophrenia-psychosis and working memory deficit-were strongly associated with [
Identifiants
pubmed: 38309322
pii: S0006-3223(24)00062-3
doi: 10.1016/j.biopsych.2024.01.019
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.