Recent progress in understanding the intracellular domain's gating and functional roles in trimeric ligand-gated ion channels.
三聚体配体门控离子通道胞内区域的功能研究进展.
Function
Gating
Intracellular domain
Review
Trimeric ligand-gated ion channels
Journal
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
ISSN: 1008-9292
Titre abrégé: Zhejiang Da Xue Xue Bao Yi Xue Ban
Pays: China
ID NLM: 100927946
Informations de publication
Date de publication:
02 Feb 2024
02 Feb 2024
Historique:
medline:
4
2
2024
pubmed:
4
2
2024
entrez:
3
2
2024
Statut:
aheadofprint
Résumé
Ligand-gated ion channels are a large category of essential ion channels, whose superfamily members may modulate their state by binding to specific ligands, allowing specific ions to pass through the cell membrane. Purinergic ligand- gated ion channel(P2X)and ASIC (acid-sensitive ion channel) are representative members of trimeric ligand-gated ion channels. Recent studies have shown that structural differences in the intracellular domain of P2X receptors (P2XR) may determine the desensitization process. The lateral fenestrations of P2XR potentially serve as a pathway for ion conduction and play a decisive role in ion selectivity. Phosphorylation of numerous amino acid residues in the P2XR is involved in regulating the activity of ion channels. Additionally, the P2XR interacts with other ligand-gated ion channel such as NMDA receptor, GABA receptor, 5-HT 配体门控离子通道是一大类重要的膜蛋白。嘌呤能配体门控离子通道（P2X）受体和酸敏感离子通道（acid-sensing ion channel，ASIC）是三聚体配体门控离子通道的代表成员。P2X受体胞内区域的结构差异可影响脱敏过程，胞内区域的侧窗可作为离子渗透到细胞内的潜在路径并对离子选择性有决定作用，胞内区域众多氨基酸残基的磷酸化参与调节离子通道的活性，此外，胞内区域与N-甲基-D-天冬氨酸受体、γ-氨基丁酸受体、5-羟色胺受体和N型乙酰胆碱受体等其他配体门控离子通道存在相互作用并介导突触可塑性等病理生理过程。ASIC胞内区域的构象变化会暴露胞内信号分子的结合位点并促进代谢信号转导，胞内区域的氨基酸Val16、Ser17、Ile18、Gln19和Ala20可以调节通道上膜表达并参与门控过程，胞内区域的PDZ结构域可与多种细胞内蛋白质如骨架蛋白CIPP和p11相互作用从而参与对受体的调控，胞内区域C端和N端的众多磷酸化位点参与了对受体的调控，此外，胞内区域参与了疼痛、缺血性中风、精神疾病、神经退行性疾病等多种病理生理过程。本文综述了P2X受体和ASIC胞内区域的结构以及在调节离子通道的门控特性和病理生理功能中的作用，以期为三聚体配体门控离子通道的药物研发提供新思路。.
Autres résumés
Type: Publisher
(chi)
配体门控离子通道是一大类重要的膜蛋白。嘌呤能配体门控离子通道（P2X）受体和酸敏感离子通道（acid-sensing ion channel，ASIC）是三聚体配体门控离子通道的代表成员。P2X受体胞内区域的结构差异可影响脱敏过程，胞内区域的侧窗可作为离子渗透到细胞内的潜在路径并对离子选择性有决定作用，胞内区域众多氨基酸残基的磷酸化参与调节离子通道的活性，此外，胞内区域与N-甲基-D-天冬氨酸受体、γ-氨基丁酸受体、5-羟色胺受体和N型乙酰胆碱受体等其他配体门控离子通道存在相互作用并介导突触可塑性等病理生理过程。ASIC胞内区域的构象变化会暴露胞内信号分子的结合位点并促进代谢信号转导，胞内区域的氨基酸Val16、Ser17、Ile18、Gln19和Ala20可以调节通道上膜表达并参与门控过程，胞内区域的PDZ结构域可与多种细胞内蛋白质如骨架蛋白CIPP和p11相互作用从而参与对受体的调控，胞内区域C端和N端的众多磷酸化位点参与了对受体的调控，此外，胞内区域参与了疼痛、缺血性中风、精神疾病、神经退行性疾病等多种病理生理过程。本文综述了P2X受体和ASIC胞内区域的结构以及在调节离子通道的门控特性和病理生理功能中的作用，以期为三聚体配体门控离子通道的药物研发提供新思路。.
Identifiants
pubmed: 38310082
doi: 10.3724/zdxbyxb-2023-0472
doi:
Types de publication
Journal Article
Langues
eng
chi
Sous-ensembles de citation
IM
Pagination
1-10Références
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