Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course.
Adrenocortical aging; Adrenocortical life-course function; Nonhuman primate
Cortisol
Glucocorticoid
Hypothalamo-pituitary-adrenal-axis
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
received:
07
09
2023
accepted:
09
01
2024
medline:
5
2
2024
pubmed:
5
2
2024
entrez:
4
2
2024
Statut:
aheadofprint
Résumé
Debate exists on life-course adrenocortical zonal function trajectories. Rapid, phasic blood steroid concentration changes, such as circadian rhythms and acute stress responses, complicate quantification. To avoid pitfalls and account for life-stage changes in adrenocortical activity indices, we quantified zonae fasciculata (ZF) and reticularis (ZR) across the life-course, by immunohistochemistry of key regulatory and functional proteins. In 28 female baboon adrenals (7.5-22.1 years), we quantified 12 key proteins involved in cell metabolism, division, proliferation, steroidogenesis (including steroid acute regulatory protein, StAR), oxidative stress, and glucocorticoid and mitochondrial function. Life-course abundance of ten ZF proteins decreased with age. Cell cycle inhibitor and oxidative stress markers increased. Seven of the 12 proteins changed in the same direction for ZR and ZF. Importantly, ZF StAR decreased, while ZR StAR was unchanged. Findings indicate ZF function decreased, and less markedly ZR function, with age. Causes and aging consequences of these changes remain to be determined.
Identifiants
pubmed: 38311700
doi: 10.1007/s11357-024-01080-9
pii: 10.1007/s11357-024-01080-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : U19AG057758
Pays : United States
Informations de copyright
© 2024. The Author(s), under exclusive licence to American Aging Association.
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