The secretory leukocyte protease inhibitor (SLPI) in pathophysiology of non-communicable diseases: Evidence from experimental studies to clinical applications.

Non-communicable diseases (NCDs) are a worldwide health issue because of their prevalence, negative impacts on human welfare, and economic costs. Protease enzymes play important roles in viral and NCD diseases. Slowing disease progression by inhibiting proteases using small-molecule inhibitors or endogenous inhibitory peptides appears to be crucial. Secretory leukocyte protease inhibitor (SLPI), an inflammatory serine protease inhibitor, maintains protease/antiprotease balance. SLPI is produced by host defense effector cells during inflammation to prevent proteolytic enzyme-induced tissue damage. The etiology of noncommunicable illnesses is linked to SLPI's immunomodulatory and tissue regeneration roles. Disease phases are associated with SLPI levels and activity changes in regional tissue and circulation. SLPI has been extensively evaluated in inflammation, but rarely in NCDs. Unfortunately, the thorough evaluation of SLPI's pathophysiological functions in NCDs in multiple research models has not been published elsewhere. In this review, data from PubMed from 2014 to 2023 was collected, analysed, and categorized into

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The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Sarawut Kumphune reports a relationship with Chiang Mai University that includes: employment and funding grants. Podsawee Mongkolpathumrat reports a relationship with Thammasat University that includes: employment. Sasimanas Unnajak reports a relationship with Kasetsart University that includes: employment and funding grants. Nitirut Nernpermpisooth reports a relationship with Naresuan University that includes: employment and funding grants. Faprathan Pikwong, Chayanisa Phutiyothin, Onnicha Srisopar, Wannapat Chouyratchakarn reports a relationship with Chiang Mai University that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.