SYT7 (synaptotagmin 7) promotes cervical squamous cell carcinoma.

Apoptosis Cervical squamous cell carcinoma Migration Proliferation SYT7

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
15 Feb 2024
Historique:
received: 01 03 2023
revised: 12 01 2024
accepted: 15 01 2024
medline: 5 2 2024
pubmed: 5 2 2024
entrez: 5 2 2024
Statut: epublish

Résumé

Cervical squamous cell carcinoma (CESC) ranks among the primary contributors to global cancer-associated mortality. However, the role mediated by synaptotagmin 7 (SYT7) in CESC remains unclear. Our study employed immunohistochemistry to assess the level of SYT7 expression in the tissue microarray. Furthermore, lentiviral shRNA transduction was utilized to establish SYT7 knockdown cell line models based on HeLa and SiHa cell lines. The functional impacts of silencing SYT7 expression

Identifiants

pubmed: 38314285
doi: 10.1016/j.heliyon.2024.e24806
pii: S2405-8440(24)00837-5
pmc: PMC10837561
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e24806

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Junying Chen reports financial support was provided by National Natural Science Foundation of China. Junying Chen reports financial support was provided by China Postdoctoral Science Foundation General Project. Junying Chen reports financial support was provided by Guangxi Medical University Training Program for Distinguished Young Scholars. Junying Chen reports financial support was provided by medical and health appropriate technology development and promotion application project of Guangxi Province. Junying Chen reports financial support was provided by Guangxi Science and Technology Project.

Auteurs

Jinbing Huang (J)

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.

Wensheng Xu (W)

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.

Qiaoqiao Huang (Q)

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.

Erling Chen (E)

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.

Junying Chen (J)

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.

Classifications MeSH