Characterization of pharyngeal contractile integral using pharyngeal manometry in children.
dysphagia
high-resolution pharyngeal manometry
pharyngeal contraction
swallowing function
Journal
Journal of pediatric gastroenterology and nutrition
ISSN: 1536-4801
Titre abrégé: J Pediatr Gastroenterol Nutr
Pays: United States
ID NLM: 8211545
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
revised:
12
07
2023
received:
30
04
2023
accepted:
10
08
2023
medline:
5
2
2024
pubmed:
5
2
2024
entrez:
5
2
2024
Statut:
aheadofprint
Résumé
Pharyngeal contractile integral (PhCI) is the product of mean pharyngeal contractile amplitude, length, and duration, and provides a single metric for the vigor of entire pharyngeal contraction. A major limitation in children is lack of characterization of PhCI on high-resolution pharyngeal manometry. We aimed to determine and compare the values of PhCI in children with the abnormal and normal videofluoroscopic study of swallow (VFSS). Children who underwent high-resolution pharyngeal and esophageal manometry (HRPM/HREM), as well as VFSS, were divided into two groups; "normal VFSS" and "abnormal VFSS" groups. PhCI was calculated from the pharyngo-esophageal manometry analysis software (MMS, v9.5, Laborie Medical Technologies), and compared in these two groups. Of 67 children, 9 had abnormal VFSS (mean age 64 ± 50 months; 66.7% males), while 58 had normal VFSS (mean age 123 ± 55 months; 47% males). The mean PhCI in abnormal and normal VFSS groups was 82.00 ± 51.90 and 147.28 ± 53.89 mmHg.s.cm, respectively (p = 0.001). Subjects with abnormal VFSS were significantly younger than those with normal VFSS (p = 0.003). However, after adjusting for the VFSS result, age was no longer related to PhCI (p = 0.364). In subgroup analysis of children presenting with dysphagia, the mean PhCI in abnormal (9 subjects) and normal (36 subjects) VFSS groups was 82.00 ± 51.90 and 141.86 ± 50.39 mmHg.s.cm, respectively (p = 0.003). PhCI was significantly lower in children with abnormal VFSS than in those with normal VFSS. We did not find a significant impact of age on PhCI in our pediatric populations.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : None
Informations de copyright
© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Références
Kovacic K, Rein LE, Szabo A, Kommareddy S, Bhagavatula P, Goday PS. Pediatric feeding disorder: a nationwide prevalence study. J Pediatr. 2021;228:126-31.e3.
Rommel N, Hamdy S. Oropharyngeal dysphagia: manifestations and diagnosis. Nat Rev Gastroenterol Hepatol. 2016;13:49-59.
Shaw SM, Martino R. The normal swallow. Otolaryngol Clin North Am. 2013;46:937-956.
Dharmarathna I, Miles A, Allen JE. Current approaches to instrumental assessment of swallowing in children. Curr Opin Otolaryngol Head Neck Surg. 2018;26:349-355.
Espitalier F, Fanous A, Aviv J, et al. International consensus (ICON) on assessment of oropharyngeal dysphagia. Eur Ann Otorhinolaryngol Head Neck Dis. 2018;135:S17-S21.
Omari TI, Ciucci M, Gozdzikowska K, et al. High-resolution pharyngeal manometry and impedance: protocols and metrics-recommendations of a high-resolution pharyngeal manometry international working group. Dysphagia. 2020;35:281-295.
O'Rourke A, Humphries K, Lazar A, Martin-Harris B. The pharyngeal contractile integral is a useful indicator of pharyngeal swallowing impairment. Neurogastroenterol Mot. 2017;29:e13144.
Cock C, Omari T. Diagnosis of swallowing disorders: how we interpret pharyngeal manometry. Curr Gastroenterol Rep. 2017;19:11.
Damrongmanee A, El-Chammas K, Fei L, Zang H, Santucci N, Kaul A. Pharyngeal and upper esophageal sphincter motor dynamics during swallow in children. Neurogastroenterol Mot. 2021;33:e13962.
Kovacic K, Kern M, Pawela L, Shaker R, Sood MR. Characteristics of high-resolution esophageal manometry in children without dysphagia. Neurogastroenterol Mot. 2022;34:e14184.
Rosen R, Garza JM, Tipnis N, Nurko S. An ANMS-NASPGHAN consensus document on esophageal and antroduodenal manometry in children. Neurogastroenterol Mot. 2018;30:e13239.
Jadcherla SR, Hasenstab KA, Osborn EK, et al. Mechanisms and management considerations of parent-chosen feeding approaches to infants with swallowing difficulties: an observational study. Sci Rep. 2021;11:19934.
Jadcherla SR, Prabhakar V, Hasenstab KA, et al. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018;84:341-347.
Aoyagi Y, Ohashi M, Ando S, et al. Effect of tongue-hold swallow on pharyngeal contractile properties in healthy individuals. Dysphagia. 2021;36:936-943.
Balasubramanian G, Sharma T, Kern M, Mei L, Sanvanson P, Shaker R. Characterization of pharyngeal peristaltic pressure variability during volitional swallowing in healthy individuals. Neurogastroenterol Mot. 2017;29:e13119.
Bayona HHG, Pizzorni N, Tack J, Goeleven A, Omari T, Rommel N. Accuracy of high-resolution pharyngeal manometry metrics for predicting aspiration and residue in oropharyngeal dysphagia patients with poor pharyngeal contractility. Dysphagia. 2022;37:1560-1575.
Nativ-Zeltzer N, Logemann JA, Zecker SG, Kahrilas PJ. Pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography-a normative study of younger and older adults. Neurogastroenterol Mot. 2016;28:721-731.
Heslin N, Regan J. Effect of effortful swallow on pharyngeal pressures during swallowing in adults with dysphagia: A pharyngeal high-resolution manometry study. Int J Speech Lang Pathol. 2022;24:190-199.
Omari TI, Dejaeger E, Tack J, Van Beckevoort D, Rommel N. Effect of bolus volume and viscosity on pharyngeal automated impedance manometry variables derived for broad dysphagia patients. Dysphagia. 2013;28:146-152.
Ryu JS, Park D, Oh Y, Lee ST, Kang JY. The effects of bolus volume and texture on pharyngeal pressure events using high-resolution manometry and its comparison with videofluoroscopic swallowing study. J Neurogastroenterol Motil. 2016;22:231-239.