Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus.
aggressive behavior
arousal
dorsal raphe nucleus
impulsivity
reward
serotonin
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
revised:
17
01
2024
received:
03
11
2023
accepted:
18
01
2024
medline:
5
2
2024
pubmed:
5
2
2024
entrez:
5
2
2024
Statut:
aheadofprint
Résumé
Aggressive behavior is instinctively driven behavior that helps animals to survive and reproduce and is closely related to multiple behavioral and physiological processes. The dorsal raphe nucleus (DRN) is an evolutionarily conserved midbrain structure that regulates aggressive behavior by integrating diverse brain inputs. The DRN consists predominantly of serotonergic (5-HT:5-hydroxytryptamine) neurons and decreased 5-HT activity was classically thought to increase aggression. However, recent studies challenge this 5-HT deficiency model, revealing a more complex role for the DRN 5-HT system in aggression. Furthermore, emerging evidence has shown that non-5-HT populations in the DRN and specific neural circuits contribute to the escalation of aggressive behavior. This review argues that the DRN serves as a multifaceted modulator of aggression, acting not only via 5-HT but also via other neurotransmitters and neural pathways, as well as different subsets of 5-HT neurons. In addition, we discuss the contribution of DRN neurons in the behavioral and physiological aspects implicated in aggressive behavior, such as arousal, reward, and impulsivity, to further our understanding of DRN-mediated aggression modulation.
Identifiants
pubmed: 38314963
doi: 10.1002/bies.202300213
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300213Subventions
Organisme : Japan Science and Technology Agency (JST) FOREST Program
ID : JPMJFR214A
Organisme : Japan Society for the Promotion of Science (JSPS) KAKENHI
ID : 22K19744
Organisme : Japan Society for the Promotion of Science (JSPS) KAKENHI
ID : 22H02660
Organisme : Astellas Foundation for Research on Metabolic Disorders
Organisme : Institute of Human Sciences at the University of Tsukuba
Informations de copyright
© 2024 Wiley Periodicals LLC.
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