The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids.
Free Fatty Acids
Learning and Memory
Lipids
Myristic Acid
Phospholipase A1
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
received:
11
05
2023
accepted:
14
12
2023
revised:
06
12
2023
medline:
6
2
2024
pubmed:
6
2
2024
entrez:
5
2
2024
Statut:
aheadofprint
Résumé
The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid landscape remain largely unexplored. The levels of saturated FFAs, particularly of myristic acid (C14:0), strongly increase during neuronal stimulation and memory acquisition, suggesting the involvement of phospholipase A1 (PLA1) activity in synaptic plasticity. Here, we show that genetic ablation of the PLA1 isoform DDHD2 in mice dramatically reduces saturated FFA responses to memory acquisition across the brain. Furthermore, DDHD2 loss also decreases memory performance in reward-based learning and spatial memory models prior to the development of neuromuscular deficits that mirror human spastic paraplegia. Via pulldown-mass spectrometry analyses, we find that DDHD2 binds to the key synaptic protein STXBP1. Using STXBP1/2 knockout neurosecretory cells and a haploinsufficient STXBP1
Identifiants
pubmed: 38316990
doi: 10.1038/s44318-024-00030-7
pii: 10.1038/s44318-024-00030-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : DHAC | National Health and Medical Research Council (NHMRC)
ID : GNT1155794
Organisme : DHAC | National Health and Medical Research Council (NHMRC)
ID : 2010901
Organisme : Department of Education and Training | Australian Research Council (ARC)
ID : DE190100565
Informations de copyright
© 2024. The Author(s).
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