Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.
Inflammation
Microglia
Obesity
Pericytes
Platelet-derived growth factor
Journal
Molecular medicine (Cambridge, Mass.)
ISSN: 1528-3658
Titre abrégé: Mol Med
Pays: England
ID NLM: 9501023
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
received:
05
10
2023
accepted:
25
01
2024
medline:
6
2
2024
pubmed:
6
2
2024
entrez:
5
2
2024
Statut:
epublish
Résumé
Pericytes are a vital component of the blood-brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic inflammation and energy metabolism in obesity. The present study investigated the impact of pericytes on the pathophysiology of obesity by focusing on platelet-derived growth factor (PDGF) signaling, which regulates pericyte functions. Tamoxifen-inducible systemic conditional PDGF receptor β knockout mice (Pdgfrb Energy consumption increased and body weight gain decreased after high-fat diet loading in Pdgfrb PDGF receptor β signaling in hypothalamic pericytes promotes polarization of macrophages by changing their secretome and contributes to the progression of obesity.
Sections du résumé
BACKGROUND
BACKGROUND
Pericytes are a vital component of the blood-brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic inflammation and energy metabolism in obesity. The present study investigated the impact of pericytes on the pathophysiology of obesity by focusing on platelet-derived growth factor (PDGF) signaling, which regulates pericyte functions.
METHODS
METHODS
Tamoxifen-inducible systemic conditional PDGF receptor β knockout mice (Pdgfrb
RESULTS
RESULTS
Energy consumption increased and body weight gain decreased after high-fat diet loading in Pdgfrb
CONCLUSIONS
CONCLUSIONS
PDGF receptor β signaling in hypothalamic pericytes promotes polarization of macrophages by changing their secretome and contributes to the progression of obesity.
Identifiants
pubmed: 38317079
doi: 10.1186/s10020-024-00793-z
pii: 10.1186/s10020-024-00793-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21Subventions
Organisme : JSPS KAKENHI
ID : JP21K08549
Organisme : JSPS KAKENHI
ID : 23H02957
Organisme : JST SPRING
ID : JPMJSP2145
Organisme : JST Moonshot R&D
ID : JPMJMS2021
Informations de copyright
© 2024. The Author(s).
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