Determination of the median lethal dose of zinc gluconate in mice and safety evaluation.
C57BL/6J mice
Dose titration
ICP-MS
Intravenous injection
Median lethal dose
Sub-lethal dose
Zinc gluconate
Journal
BMC pharmacology & toxicology
ISSN: 2050-6511
Titre abrégé: BMC Pharmacol Toxicol
Pays: England
ID NLM: 101590449
Informations de publication
Date de publication:
05 Feb 2024
05 Feb 2024
Historique:
received:
18
05
2023
accepted:
18
01
2024
medline:
6
2
2024
pubmed:
6
2
2024
entrez:
5
2
2024
Statut:
epublish
Résumé
Zinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous injection and the safety evaluation of animal models for ZG. This study aims to determine the safe dose range of ZG for intravenous injection in C57BL/6J mice. A Dose titration experiment was conducted to determine the LD The dose titration experiment determined the LD The appropriate dose range of ZG for intravenous injection in C57BL/6J mice was clarified, providing a reference for future experimental research.
Sections du résumé
BACKGROUND
BACKGROUND
Zinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous injection and the safety evaluation of animal models for ZG. This study aims to determine the safe dose range of ZG for intravenous injection in C57BL/6J mice.
METHODS
METHODS
A Dose titration experiment was conducted to determine the LD
RESULTS
RESULTS
The dose titration experiment determined the LD
CONCLUSION
CONCLUSIONS
The appropriate dose range of ZG for intravenous injection in C57BL/6J mice was clarified, providing a reference for future experimental research.
Identifiants
pubmed: 38317260
doi: 10.1186/s40360-024-00736-8
pii: 10.1186/s40360-024-00736-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15Informations de copyright
© 2024. The Author(s).
Références
Wang Z, et al. Effect of orally administered hydroxypropyl chitosan on the levels of iron, copper, zinc and calcium in mice. Int J Biol Macromol. 2014;64:25–9.
pubmed: 24296411
doi: 10.1016/j.ijbiomac.2013.11.016
Wan Y, Zhang B. The impact of zinc and zinc homeostasis on the intestinal mucosal barrier and intestinal diseases. Biomolecules. 2022;12(7):900.
pubmed: 35883455
pmcid: 9313088
doi: 10.3390/biom12070900
Ohashi W, et al. Maintenance of intestinal epithelial homeostasis by zinc transporters. Dig Dis Sci. 2019;64:2404–15.
pubmed: 30830525
doi: 10.1007/s10620-019-05561-2
Miyoshi Y, Tanabe S, Suzuki T. Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression. Am J Physiology-Gastrointestinal Liver Physiol. 2016;311(1):G105–16.
doi: 10.1152/ajpgi.00405.2015
Wiegand S, et al. Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice. Sci Rep. 2017;7(1):45649.
pubmed: 28361997
pmcid: 5374507
doi: 10.1038/srep45649
Camilleri M. What is the leaky gut? Clinical considerations in humans. Curr Opin Clin Nutr Metabolic Care. 2021;24(5):473–82.
doi: 10.1097/MCO.0000000000000778
Thompson MW. Regulation of zinc-dependent enzymes by metal carrier proteins. Biometals. 2022;35(2):187–213.
pubmed: 35192096
pmcid: 8862405
doi: 10.1007/s10534-022-00373-w
Torres A, Pedersen B, Guma M. Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes. Front Immunol. 2022;13:984408.
pubmed: 36341411
pmcid: 9632162
doi: 10.3389/fimmu.2022.984408
Hussain M, et al. Recent developments in Zn-Based biodegradable materials for Biomedical Applications. J Funct Biomaterials. 2022;14(1):1.
doi: 10.3390/jfb14010001
Anik TR, et al. Zn Supplementation mitigates Drought effects on Cotton by improving photosynthetic performance and antioxidant defense mechanisms. Antioxidants. 2023;12(4):854.
pubmed: 37107228
pmcid: 10135281
doi: 10.3390/antiox12040854
Asle-Mohammadi Z et al. Foliar Application of Fe, Zn, and Mn as a practical strategy to alleviate the Soil Cu Toxicity and stimulate the physiological and Biochemical Properties of Peppermint (Mentha Piperita L). J Soil Sci Plant Nutr, 2023: p. 1–18.
Skalny AV, et al. Gut microbiota as a mediator of essential and toxic effects of zinc in the intestines and other tissues. Int J Mol Sci. 2021;22(23):13074.
pubmed: 34884881
pmcid: 8658153
doi: 10.3390/ijms222313074
He Y, et al. Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis. Life Sci. 2019;233:116697.
pubmed: 31351968
doi: 10.1016/j.lfs.2019.116697
Zackular JP, et al. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nat Med. 2016;22(11):1330–4.
pubmed: 27668938
pmcid: 5101143
doi: 10.1038/nm.4174
Murray M, et al. Modulation of murine lymphocyte and macrophage proliferation by parenteral zinc. Clin Exp Immunol. 1983;53(3):744.
pubmed: 6616965
pmcid: 1535646
Andriollo-Sanchez M, et al. Toxic effects of iterative intraperitoneal administration of zinc gluconate in rats. Volume 103. Basic & clinical pharmacology & toxicology; 2008. pp. 267–72. 3.
Hsieh H, Horwath MC, Genter MB. Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice. Neurotoxicology. 2017;58:130–6.
pubmed: 27979773
doi: 10.1016/j.neuro.2016.12.003
Vang L, et al. Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus. PLoS Negl Trop Dis. 2021;15(3):e0009195.
pubmed: 33711018
pmcid: 7990201
doi: 10.1371/journal.pntd.0009195
Li H, et al. Mushroom poisoning outbreaks—China, 2020. China CDC Weekly. 2021;3(3):41.
pubmed: 34594953
pmcid: 8392932
doi: 10.46234/ccdcw2021.014
Adeyi O et al. Sub-acute exposure to Sodium Selenite-induced Dyslipidemia, ATPase-independent Electrolytes disruption and tissue damage in male Wistar rats. Afr Sci, 2022. 21(3).
Gholamine B, et al. Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats. Drug Chem Toxicol. 2021;44(4):341–52.
pubmed: 30907158
doi: 10.1080/01480545.2019.1591434
Onmaz DE, et al. Development and validation of a sensitive, fast and simple LC-MS/MS method for the quantitation of favipiravir in human serum. J Chromatogr B. 2021;1176:122768.
doi: 10.1016/j.jchromb.2021.122768
Wilschefski SC, Baxter MR. Inductively coupled plasma mass spectrometry: introduction to analytical aspects. Clin Biochemist Reviews. 2019;40(3):115.
doi: 10.33176/AACB-19-00024
Morgan CI, et al. Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen. J Inflamm. 2011;8:1–10.
doi: 10.1186/1476-9255-8-36
Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database of Systematic Reviews, 2016(12).
Chang AB, et al. Zinc and vitamin a supplementation in indigenous Australian children hospitalised with lower respiratory tract infection: a randomised controlled trial. Med J Aust. 2006;184(3):107–12.
pubmed: 16460294
doi: 10.5694/j.1326-5377.2006.tb00147.x
Dhingra U, et al. Lower-dose zinc for childhood diarrhea—A randomized, multicenter trial. N Engl J Med. 2020;383(13):1231–41.
pubmed: 32966722
pmcid: 7466932
doi: 10.1056/NEJMoa1915905
O’Kane D, et al. Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model. Biometals. 2018;31:821–34.
pubmed: 29974287
doi: 10.1007/s10534-018-0125-3
Salimi A, et al. Toxicity of microwave-assisted biosynthesized zinc nanoparticles in mice: a preliminary study. Artif Cells Nanomed Biotechnol. 2019;47(1):1846–58.
pubmed: 31066299
doi: 10.1080/21691401.2019.1611592
Nguyen VD, et al. Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation. J Mol Biol. 2011;406(3):503–15.
pubmed: 21215271
doi: 10.1016/j.jmb.2010.12.039
Wang X, et al. Neuroprotective effect of umbilical cord mesenchymal stem cell-derived exosomes on hippocampal neurons in mice with intracerebral hemorrhage. Chin J Tissue Eng Res. 2022;26(31):4928.
da Silva Júnior FJTM, et al. Study of inorganic elements in different organs and tissues of amazonian manatee (Trichechus inunguis) from Brazil. Environmental Science and Pollution Research; 2022. pp. 1–10.
Hinds LA, et al. Acute oral toxicity of zinc phosphide: an assessment for wild house mice (Mus musculus). Integr Zool. 2023;18(1):63–75.
pubmed: 35651323
doi: 10.1111/1749-4877.12666
de Santo FB, et al. Ecotoxicity of the isoxaflutole herbicide to soil invertebratesEcotoxicity of isoxaflutole herbicide to soil invertebrates. Revista De Ciências Agroveterinárias. 2020;19(2):217–23.
doi: 10.5965/223811711922020217
Saganuwan SA. Comparative therapeutic index, lethal time and safety margin of various toxicants and snake antivenoms using newly derived and old formulas. BMC Res Notes. 2020;13:1–7.
doi: 10.1186/s13104-020-05134-x
Rehman SU, Choe K, Yoo HH. Review on a traditional herbal medicine, Eurycoma Longifolia Jack (Tongkat Ali): its traditional uses, chemistry, evidence-based pharmacology and toxicology. Molecules. 2016;21(3):331.
pubmed: 26978330
pmcid: 6274257
doi: 10.3390/molecules21030331
Lai L, et al. In vivo target bio-imaging of Alzheimer’s disease by fluorescent zinc oxide nanoclusters. Biomaterials Sci. 2016;4(7):1085–91.
doi: 10.1039/C6BM00233A
Lai L, et al. In vivo biosynthesized zinc and iron oxide nanoclusters for high spatiotemporal dual-modality bioimaging of Alzheimer’s disease. Langmuir. 2017;33(36):9018–24.
pubmed: 28806518
doi: 10.1021/acs.langmuir.7b01516
Zhao C, et al. In vivo target bio-imaging of cerebral ischemic stroke by real-time labeling of zinc. RSC Adv. 2016;6(112):110525–34.
doi: 10.1039/C6RA23507G
Li X, et al. Zinc improves functional recovery by regulating the secretion of granulocyte colony stimulating factor from microglia/macrophages after spinal cord injury. Front Mol Neurosci. 2019;12:18.
pubmed: 30774583
pmcid: 6367229
doi: 10.3389/fnmol.2019.00018
Choi H, et al. Sublethal doses of zinc protect rat neural stem cells against hypoxia through activation of the PI3K pathway. Stem Cells Dev. 2019;28(12):769–80.
pubmed: 30896367
doi: 10.1089/scd.2018.0138
Song Y, et al. Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr. 2009;139(9):1626–31.
pubmed: 19625698
pmcid: 3151020
doi: 10.3945/jn.109.106369
Osredkar J, Sustar N. Copper and zinc, biological role and significance of copper/zinc imbalance. J Clin Toxicol S. 2011;3(2161):0495.
Dey A, et al. Optically engineered ZnO nanoparticles: excitable at visible wavelength and lowered cytotoxicity towards bioimaging applications. Appl Surf Sci. 2022;592:153303.
doi: 10.1016/j.apsusc.2022.153303
Singh H, et al. Nanomaterial-based fluorescent sensors for the detection of lead ions. J Hazard Mater. 2021;407:124379.
pubmed: 33309138
doi: 10.1016/j.jhazmat.2020.124379
Hulsbosch LP, et al. The first trimester plasma copper–zinc ratio is independently related to pregnancy-specific psychological distress symptoms throughout pregnancy. Nutrition. 2023;109:111938.
pubmed: 36736090
doi: 10.1016/j.nut.2022.111938
Su C-K. Review of 3D-Printed functionalized devices for chemical and biochemical analysis. Anal Chim Acta. 2021;1158:338348.
pubmed: 33863415
doi: 10.1016/j.aca.2021.338348
Kaneko S, et al. Serum zinc concentration correlates with ferritin concentration in patients undergoing peritoneal dialysis: a cross-sectional study. Front Med. 2020;7:537586.
doi: 10.3389/fmed.2020.537586
Moran VH, et al. The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose-response meta-analysis. Nutrients. 2012;4(8):841–58.
pubmed: 23016120
pmcid: 3448075
doi: 10.3390/nu4080841
Li L, et al. Non-linear association of serum molybdenum and linear association of serum zinc with nonalcoholic fatty liver disease: multiple-exposure and mendelian randomization approach. Sci Total Environ. 2020;720:137655.
pubmed: 32146412
doi: 10.1016/j.scitotenv.2020.137655