Periodontitis in ischemic stroke: impact of

Porphyromonas gingivalis endovascular therapy ischemic stroke neutrophils periodontitis thrombus

Journal

Research and practice in thrombosis and haemostasis
ISSN: 2475-0379
Titre abrégé: Res Pract Thromb Haemost
Pays: United States
ID NLM: 101703775

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 08 06 2023
revised: 11 12 2023
accepted: 20 12 2023
medline: 6 2 2024
pubmed: 6 2 2024
entrez: 6 2 2024
Statut: epublish

Résumé

Periodontitis is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association remain unclear. Our objective was to determine whether The presence of Pg gingipain in 175 consecutive thrombi from patients with large vessel occlusion stroke enrolled in the multicenter research cohort compoCLOT was investigated by immunostaining. Thrombus blood cell composition according to gingipain status was analyzed in a subset of 63 patients. Pg gingipain immunostaining was positive in 33.7% of thrombi (95% CI, 26.7%-40.8%). The percentage of near to complete reperfusion (modified Thrombolysis in Cerebral Infarction Score 2c/3) at the end of the procedure was lower in the Pg Our results indicate that intrathrombus Pg gingipain is associated with increased neutrophil content and resistance to endovascular therapy.

Sections du résumé

Background UNASSIGNED
Periodontitis is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association remain unclear.
Objectives UNASSIGNED
Our objective was to determine whether
Methods UNASSIGNED
The presence of Pg gingipain in 175 consecutive thrombi from patients with large vessel occlusion stroke enrolled in the multicenter research cohort compoCLOT was investigated by immunostaining. Thrombus blood cell composition according to gingipain status was analyzed in a subset of 63 patients.
Results UNASSIGNED
Pg gingipain immunostaining was positive in 33.7% of thrombi (95% CI, 26.7%-40.8%). The percentage of near to complete reperfusion (modified Thrombolysis in Cerebral Infarction Score 2c/3) at the end of the procedure was lower in the Pg
Conclusion UNASSIGNED
Our results indicate that intrathrombus Pg gingipain is associated with increased neutrophil content and resistance to endovascular therapy.

Identifiants

DOI: 10.1016/j.rpth.2023.102313 PMID: 38318152 PMC: PMC10840352
pubmed: 38318152
doi: 10.1016/j.rpth.2023.102313
pii: S2475-0379(23)05741-2
pmc: PMC10840352
doi:

Types de publication

Journal Article

Langues

eng

Pagination

102313

Informations de copyright

© 2024 The Authors.

Auteurs

Aurélien Freiherr Von Seckendorff (A)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.
Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Mialitiana Solo Nomenjanahary (MS)

Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Julien Labreuche (J)

Department of Biostatistics, Centre Hospitalier Universitaire Lille, Lille, France.

Véronique Ollivier (V)

Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Lucas Di Meglio (L)

Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Sebastien Dupont (S)

Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Mylène Hamdani (M)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.

Nahida Brikci-Nigassa (N)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.

Adrian Brun (A)

Laboratory of Orofacial Pathologies, Imaging and Biotherapies URP2496, Unité de Formation et de Recherche Odontologie, Faculté de Santé, Université Paris Cité, Montrouge, France.
Division of Periodontology, Department of Oral Medicine, Assisantance Publique Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.

Perrine Boursin (P)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.

Michel Piotin (M)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.
Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Mikael Mazighi (M)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.
Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.
Fédération Hospitalo-Universitaire Neurovasc, Department of Neurology, Hopital Lariboisière, Assisantance Publique Hôpitaux de Paris, Paris, France.
Department of Neurology, Hôpital Lariboisière, Assisantance Publique Hôpitaux de Paris Nord, Paris, France.

Benoit Ho-Tin-Noé (B)

Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.

Jean-Philippe Desilles (JP)

Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France.
Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Unité de Formation et de Recherche Pharmacie, Université Paris Cité, Paris, France.
Fédération Hospitalo-Universitaire Neurovasc, Department of Neurology, Hopital Lariboisière, Assisantance Publique Hôpitaux de Paris, Paris, France.

Sandrine Delbosc (S)

Institut National de la Santé et de la Recherche Médicale, Laboratory for Vascular Translational Research, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France.

Classifications MeSH