Sex disparities in clinical features and burden of narcolepsy type 1.
depression
gender
impairment
narcolepsy
sex
sleepiness
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
06 Feb 2024
06 Feb 2024
Historique:
revised:
28
12
2023
received:
29
10
2023
accepted:
17
01
2024
medline:
6
2
2024
pubmed:
6
2
2024
entrez:
6
2
2024
Statut:
aheadofprint
Résumé
To investigate potential sex-related differences in patients with narcolepsy type 1, we carried out an analysis of baseline data from 93 women and 89 men with narcolepsy type 1 who participated in the TElemedicine for NARcolepsy (TENAR) trial. The following data were considered: sociodemographics; diagnostic (disease history, polysomnography, orexin, human leukocyte antigen) and clinical features, including sleepiness (Epworth Sleepiness Scale), cataplexy and other narcolepsy symptoms; disease severity (Narcolepsy Severity Scale); pharmacological treatment; depressive symptoms (Beck Depression Inventory); and self-reported relevance of eight narcolepsy-related issues. We found that, compared with men, significantly more women reported automatic behaviours (55.4% versus 40%) and had higher Epworth Sleepiness Scale (median 10 versus 9) and Beck Depression Inventory scores (median 10.5 versus 5), and there was a trend for a higher Narcolepsy Severity Scale total score in women (median 19 versus 18, p = 0.057). More women than men were officially recognized as having a disability (38% versus 22.5%) and considered 5/8 narcolepsy-related issues investigated as a relevant problem. More severe sleepiness and a greater narcolepsy-related burden in women could mirror sex differences present in the general population, or may be related to suboptimal management of narcolepsy type 1 or to more severe depressive symptoms in women. Future studies and guidelines should address these aspects.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14157Subventions
Organisme : Ministero della Salute
ID : RF-2016-02364742
Organisme : Ricerca Corrente
Informations de copyright
© 2024 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
Références
American Academy of Sleep Medicine (Ed.). (2014). International classification of sleep disorders (3rd ed.). American Academy of Sleep Medicine.
Baker, F. C., Wolfson, A. R., & Lee, K. A. (2009). Association of sociodemographic, lifestyle, and health factors with sleep quality and daytime sleepiness in women: Findings from the 2007 National Sleep Foundation “sleep in America poll”. Journal of Women's Health (2002), 18(6), 841-849. https://doi.org/10.1089/jwh.2008.0986
Barker, E. C., Flygare, J., Paruthi, S., & Sharkey, K. M. (2020). Living with narcolepsy: Current management strategies, future prospects, and overlooked real-life concerns. Nat Sci Sleep, 12, 453-466. https://doi.org/10.2147/NSS.S162762
Boyes, J., Drakatos, P., Jarrold, I., Smith, J., & Steier, J. (2017). The use of an online Epworth sleepiness scale to assess excessive daytime sleepiness. Sleep & Breathing, 21(2), 333-340. https://doi.org/10.1007/s11325-016-1417-x
Coffey, A. A., Joyal, A. A., Yamanaka, A., & Scammell, T. E. (2021). The impacts of age and sex in a mouse model of childhood narcolepsy. Frontiers in Neuroscience, 15, 644757. https://doi.org/10.3389/fnins.2021.644757
Ingravallo, F., Vignatelli, L., Pagotto, U., Vandi, S., Moresco, M., Mangiaruga, A., Oriolo, C., Zenesini, C., Pizza, F., & Plazzi, G. (2020). Protocols of a diagnostic study and a randomized controlled non-inferiority trial comparing televisits vs standard in-person outpatient visits for narcolepsy diagnosis and care: TElemedicine for NARcolepsy (TENAR). BMC Neurol, 20(1), 176. https://doi.org/10.1186/s12883-020-01762-9
Jara, C. O., Popp, R., Zulley, J., Hajak, G., & Geisler, P. (2011). Determinants of depressive symptoms in narcoleptic patients with and without cataplexy. J NervMent Dis., 199(5), 329-334. https://doi.org/10.1097/NMD.0b013e3182174fd3
Kim, H., & Young, T. (2005). Subjective daytime sleepiness: Dimensions and correlates in the general population. Sleep, 28(5), 625-634. https://doi.org/10.1093/sleep/28.5.625
Konjarski, M., Murray, G., Lee, V. V., & Jackson, M. L. (2018). Reciprocal relationships between daily sleep and mood: A systematic review of naturalistic prospective studies. Sleep Medicine Reviews, 42, 47-58. https://doi.org/10.1016/j.smrv.2018.05.005
Luca, G., Haba-Rubio, J., Dauvilliers, Y., Lammers, G. J., Overeem, S., Donjacour, C. E., Mayer, G., Javidi, S., Iranzo, A., Santamaria, J., Peraita-Adrados, R., Hor, H., Kutalik, Z., Plazzi, G., Poli, F., Pizza, F., Arnulf, I., Lecendreux, M., Bassetti, C., … European Narcolepsy Network (EU-NN). (2013). Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: A European narcolepsy network study. Journal of Sleep Research, 22(5), 482-495. https://doi.org/10.1111/jsr.12044
Nevsimalova, S., Skibova, J., Galuskova, K., Prihodova, I., Dostalova, S., Maurovich-Horvat, E., & Šonka, K. (2022). Central disorders of Hypersomnolence: Association with fatigue, depression and sleep inertia prevailing in women. Brain Sciences, 12(11), 1491. https://doi.org/10.3390/brainsci12111491
Piilgaard, L., Rose, L., Gylling Hviid, C., Kohlmeier, K. A., & Kornum, B. R. (2022). Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model. Sleep, 45(7), zsac058. https://doi.org/10.1093/sleep/zsac058
Sun, Y., Tisdale, R., Park, S., Ma, S. C., Heu, J., Haire, M., Allocca, G., Yamanaka, A., Morairty, S. R., & Kilduff, T. S. (2022). The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female orexin/tTA; TetO-DTA mice. Sleep, 45(12), zsac039. https://doi.org/10.1093/sleep/zsac039
Ulander, M., Rångtell, F., & Theorell-Haglöw, J. (2021). Sleep measurements in women. Sleep Medicine Clinics, 16(4), 635-648. https://doi.org/10.1016/j.jsmc.2021.07.004
Won, C., Mahmoudi, M., Qin, L., Purvis, T., Mathur, A., & Mohsenin, V. (2014). The impact of gender on timeliness of narcolepsy diagnosis. J Clin Sleep Med, 10(1), 89-95. https://doi.org/10.5664/jcsm.33708
Zhang, Z., Dauvilliers, Y., Plazzi, G., Mayer, G., Lammers, G. J., Santamaria, J., Partinen, M., Overeem, S., del Rio Villegas, R., Sonka, K., Peraita-Adrados, R., Heinzer, R., Wierzbicka, A., Högl, B., Manconi, M., Feketeova, E., da Silva, A. M., Bušková, J., Bassetti, C. L. A., … Khatami, R. (2022). Idling for decades: A European study on risk factors associated with the delay before a narcolepsy diagnosis. Nat Sci. Sleep, 14, 1031-1047. https://doi.org/10.2147/NSS.S359980