Efficacy and Safety of Oteseconazole in Recurrent Vulvovaginal Candidiasis.


Journal

NEJM evidence
ISSN: 2766-5526
Titre abrégé: NEJM Evid
Pays: United States
ID NLM: 9918317485806676

Informations de publication

Date de publication:
Aug 2022
Historique:
medline: 1 8 2022
pubmed: 1 8 2022
entrez: 6 2 2024
Statut: ppublish

Résumé

Oteseconazole for Recurrent Vulvovaginal CandidiasisThese two phase 3, multicenter RCTs evaluated the efficacy of oral oteseconazole in treating recurrent vulvovaginal candidiasis (RVVC). Among women with a history of RVVC, oteseconazole treatment through week 48 led to acute VVC recurrence in about 5% of patients compared to about 40% of patients receiving placebo, P<0.001. Oteseconazole showed potent activity against fluconazole-resistant

Identifiants

pubmed: 38319878
doi: 10.1056/EVIDoa2100055
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

EVIDoa2100055

Auteurs

Jack D Sobel (JD)

Department of Internal Medicine, School of Medicine, Wayne State University, Detroit.

Gilbert Donders (G)

Department of Obstetrics and Gynecology, Regional Hospital H Hart Tienen, Femicare Research Tienen, University Hospital Antwerp, Tienen, Belgium.

Thorsten Degenhardt (T)

Mycovia Pharmaceuticals, Inc., Durham, NC.

Karen Person (K)

Mycovia Pharmaceuticals, Inc., Durham, NC.

Stacey Curelop (S)

Mycovia Pharmaceuticals, Inc., Durham, NC.

Mahmoud Ghannoum (M)

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland.

Stephen R Brand (SR)

Mycovia Pharmaceuticals, Inc., Durham, NC.

Classifications MeSH