RNA Interference Therapy Targeting Apolipoprotein C-III in Hypertriglyceridemia.

Journal

NEJM evidence
ISSN: 2766-5526
Titre abrégé: NEJM Evid
Pays: United States
ID NLM: 9918317485806676

Informations de publication

Date de publication:
Dec 2023
Historique:
medline: 7 2 2024
pubmed: 7 2 2024
entrez: 6 2 2024
Statut: ppublish

Résumé

APOC3-Targeting RNAi for HypertriglyceridemiaThis randomized controlled trial examined the safety and side effects of the small interfering RNA ARO-APOC3 in healthy volunteers and patients with hypertriglyceridemia and chylomicronemia. ARO-APOC3 was associated with few adverse events and no dose-limiting toxicities.

Identifiants

DOI: 10.1056/EVIDoa2200325 PMID: 38320498
pubmed: 38320498
doi: 10.1056/EVIDoa2200325
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

EVIDoa2200325

Auteurs

Daniel Gaudet (D)

Department of Medicine, Université de Montréal and ECOGENE 21 Clinical Research Center, Chicoutimi, Quebec, QC, Canada.

Peter Clifton (P)

Royal Adelaide Hospital, Adelaide, SA, Australia.

David Sullivan (D)

NSW Health Pathology, Royal Prince Alfred Hospital, Sydney.

John Baker (J)

Middlemore Hospital, Auckland, New Zealand.

Christian Schwabe (C)

Auckland Clinical Studies, Auckland, New Zealand.

Susan Thackwray (S)

University of the Sunshine Coast, Sippy Downs, QLD, Australia.

Russell Scott (R)

NZ Clinical Research, Christchurch, New Zealand.

James Hamilton (J)

Arrowhead Pharmaceuticals, Inc., Pasadena, CA.

Bruce Given (B)

Arrowhead Pharmaceuticals, Inc., Pasadena, CA.

Stacey Melquist (S)

Arrowhead Pharmaceuticals, Inc., Pasadena, CA.

Rong Zhou (R)

Arrowhead Pharmaceuticals, Inc., Pasadena, CA.

Ting Chang (T)

Arrowhead Pharmaceuticals, Inc., Pasadena, CA.

Javier San Martin (J)

Arrowhead Pharmaceuticals, Inc., Pasadena, CA.

Gerald F Watts (GF)

School of Medicine, University of Western Australia, Perth, Australia.
Department of Cardiology, Royal Perth Hospital, Perth, Australia.

Ira J Goldberg (IJ)

NYU Grossman School of Medicine, New York.

Joshua W Knowles (JW)

Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, School of Medicine, Stanford, CA.

Robert A Hegele (RA)

Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Christie M Ballantyne (CM)

Baylor College of Medicine, Houston.

Classifications MeSH