Apixaban versus Aspirin for Embolic Stroke of Undetermined Source.

Journal

NEJM evidence
ISSN: 2766-5526
Titre abrégé: NEJM Evid
Pays: United States
ID NLM: 9918317485806676

Informations de publication

Date de publication:
Jan 2024
Historique:
medline: 7 2 2024
pubmed: 7 2 2024
entrez: 6 2 2024
Statut: ppublish

Résumé

Apixaban versus Aspirin for Embolic StrokeIn a trial of 352 patients with embolic stroke of undetermined source, 5 mg of apixaban administered twice daily was compared with 100 mg of aspirin administered once daily for the prevention of recurrent ischemic strokes. At 12 months, 13.6% of patients given apixaban had new ischemic lesions on magnetic resonance imaging compared with 16.0% of patients given aspirin, and the rates of clinically relevant bleeding were also comparable.

Identifiants

DOI: 10.1056/EVIDoa2300235 PMID: 38320511
pubmed: 38320511
doi: 10.1056/EVIDoa2300235
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

EVIDoa2300235

Auteurs

Tobias Geisler (T)

Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Timea Keller (T)

Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Peter Martus (P)

Institute for Clinical Epidemiology and Applied Biometry, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.

Khouloud Poli (K)

Department of Neurology & Stroke, Eberhard Karls University Tübingen, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.

Lina Maria Serna-Higuita (LM)

Institute for Clinical Epidemiology and Applied Biometry, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.

Juergen Schreieck (J)

Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Meinrad Gawaz (M)

Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Johannes Tünnerhoff (J)

Department of Neurology & Stroke, Eberhard Karls University Tübingen, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.

Paula Bombach (P)

Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.
Department of Neurology and Interdisciplinary Neuro-Oncology, Eberhard Karls University Tübingen, Tübingen, Germany.

Thomas Nägele (T)

Department of Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Uwe Klose (U)

Department of Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Parwez Aidery (P)

Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Patrick Groga-Bada (P)

Department of Cardiology and Angiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Andrea Kraft (A)

Department of Neurology, Krankenhaus Martha-Maria Halle-Doelau, Halle (Saale), Germany.

Frank Hoffmann (F)

Department of Neurology, Krankenhaus Martha-Maria Halle-Doelau, Halle (Saale), Germany.

Carsten Hobohm (C)

Department of Neurology, Carl-von-Basedow Klinikum Merseburg, Merseburg, Germany.

Katrin Naupold (K)

Department of Neurology, Carl-von-Basedow Klinikum Merseburg, Merseburg, Germany.

Ludwig Niehaus (L)

Department of Neurology, Rems-Murr Kliniken, Winnenden, Germany.

Marc Wolf (M)

Department of Neurology, Klinikum Stuttgart, Stuttgart, Germany.

Hansjörg Bäzner (H)

Department of Neurology, Klinikum Stuttgart, Stuttgart, Germany.

Jan Liman (J)

Department of Neurology, Klinikum Nürnberg, Nürnberg, Germany.
Clinic for Neurology, University Hospital Göttingen, Göttingen, Germany.

Rolf Wachter (R)

Department of Cardiology, University Hospital Leipzig, Leipzig, Germany.
Clinic for Cardiology and Pneumology, University Medicine Göttingen, Göttingen, Germany.
German Center for Cardiovascular Research, Göttingen, Germany.

Hubert Kimmig (H)

Department of Neurology, Schwarzwald-Baar Klinikum, Villingen-Schwenningen, Germany.

Werner Jung (W)

Department of Cardiology, Schwarzwald-Baar Klinikum, Villingen-Schwenningen, Germany.

Roman Huber (R)

Department of Neurology, Klinikum Friedrichshafen, Friedrichshafen, Germany.

Regina Feurer (R)

Department of Neurology, Klinikum Friedrichshafen, Friedrichshafen, Germany.

Alfred Lindner (A)

Department of Neurology, Marienhospital Stuttgart, Stuttgart, Germany.

Katharina Althaus (K)

Department of Neurology, University Hospital Ulm, Ulm, Germany.

Felix J Bode (FJ)

Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, Germany.

Gabor C Petzold (GC)

Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, Germany.

Thanh N Nguyen (TN)

Department of Radiology, Boston Medical Center, Boston.
Department of Neurology, Boston Medical Center, Boston.

Brian Mac Grory (B)

Duke Clinical Research Institute, Durham, NC.
Department of Neurology, Duke University School of Medicine, Durham, NC.

Matthew Schrag (M)

Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN.

Jan C Purrucker (JC)

Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.

Christine S Zuern (CS)

Department of Neurology, Klinikum Nürnberg, Nürnberg, Germany.
Department of Cardiology, Universitätsspital Basel, Basel, Switzerland.

Ulf Ziemann (U)

Department of Neurology & Stroke, Eberhard Karls University Tübingen, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.

Sven Poli (S)

Department of Neurology & Stroke, Eberhard Karls University Tübingen, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.

Classifications MeSH