High-Dose Glucocorticoids for the Treatment of Sudden Hearing Loss.

Journal

NEJM evidence
ISSN: 2766-5526
Titre abrégé: NEJM Evid
Pays: United States
ID NLM: 9918317485806676

Informations de publication

Date de publication:
Jan 2024
Historique:
medline: 7 2 2024
pubmed: 7 2 2024
entrez: 6 2 2024
Statut: ppublish

Résumé

High-Dose Glucocorticoids for Sudden Hearing LossThis trial compared courses of high-dose intravenous prednisolone or high-dose oral dexamethasone versus standard-dose oral prednisone in adults with idiopathic sudden sensorineural hearing loss. At 30 days, systemic high-dose glucocorticoid therapy was not superior to a lower-dose regimen with respect to change in hearing threshold, and it was associated with a higher risk of side effects.

Identifiants

DOI: 10.1056/EVIDoa2300172 PMID: 38320514
pubmed: 38320514
doi: 10.1056/EVIDoa2300172
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

EVIDoa2300172

Auteurs

Stefan K Plontke (SK)

Department of Otorhinolaryngology, Head & Neck Surgery, University Medicine Halle, Halle (Saale), Germany.

Matthias Girndt (M)

Department of Internal Medicine, University Medicine Halle, Halle (Saale), Germany.

Christoph Meisner (C)

Robert Bosch Society for Medical Research, Robert Bosch Hospital, Stuttgart, Germany.

Imma Fischer (I)

Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.

Iris Böselt (I)

Coordination Centre for Clinical Trials, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Jan Löhler (J)

Scientific Institute for Applied Oto-Rhino-Laryngology of the German Professional Association of ENT Surgeons, Bad Bramstedt, Germany.

Beatrice Ludwig-Kraus (B)

Department of Laboratory Medicine, Central Laboratory, University Hospital Halle, Halle (Saale), Germany.

Michael Richter (M)

Coordination Centre for Clinical Trials, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Jörg Steighardt (J)

Coordination Centre for Clinical Trials, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Bernd Reuter (B)

Department of Otorhinolaryngology/Plastic Surgery, SRH Zentralklinikum Suhl, Suhl, Germany.

Christoph Böttcher (C)

Department of Otorhinolaryngology/Plastic Surgery, SRH Zentralklinikum Suhl, Suhl, Germany.
ENT Practice, Bad Neustadt, Germany.

Jörg Langer (J)

ENT Department, AMEOS Clinic Halberstadt, Halberstadt, Germany.

Wolfram Pethe (W)

ENT Department, AMEOS Clinic Halberstadt, Halberstadt, Germany.

Ingmar Seiwerth (I)

Department of Otorhinolaryngology, Head & Neck Surgery, University Medicine Halle, Halle (Saale), Germany.

Nebojsa Jovanovic (N)

Department of Otorhinolaryngology, Head and Neck Surgery, Plastic Surgery, University Hospital of Giessen and Marburg, Giessen, Germany.

Wilma Großmann (W)

Department of Otorhinolaryngology, Head and Neck Surgery "Otto Körner," Rostock University Medical Center, Rostock, Germany.

Andrea Kienle-Gogolok (A)

ENT Practice, Bad Schönborn, Germany.

Andreas Boehm (A)

ENT Department, Hospital St. Georg gGmbH, Leipzig, Germany.

Marcus Neudert (M)

Department of Otorhinolaryngology, Head and Neck Surgery, Technical University Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden, Germany.

Marc Diensthuber (M)

Department of Otorhinolaryngology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.

Andreas Müller (A)

Department Otorhinolaryngology/Plastic Surgery, SRH Wald-Klinikum Gera gGmbH, Gera, Germany.

Stefan Dazert (S)

Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth Hospital, Ruhr University Bochum, Bochum, Germany.

Orlando Guntinas-Lichius (O)

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

Joachim Hornung (J)

Department of Otorhinolaryngology and Head and Neck Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.

Veronika Vielsmeier (V)

Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany.

Joachim Stadler (J)

Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich-Braun-Klinikum gGmbH, Zwickau, Germany.

Torsten Rahne (T)

Department of Otorhinolaryngology, Head & Neck Surgery, University Medicine Halle, Halle (Saale), Germany.

Classifications MeSH