A Randomized Trial of Nafamostat for Covid-19.

Journal

NEJM evidence
ISSN: 2766-5526
Titre abrégé: NEJM Evid
Pays: United States
ID NLM: 9918317485806676

Informations de publication

Date de publication:
Nov 2023
Historique:
medline: 7 2 2024
pubmed: 7 2 2024
entrez: 6 2 2024
Statut: ppublish

Résumé

A Randomized Trial of Nafamostat for Covid-19Nafamostat mesylate is a potent in vitro antiviral that inhibits the host transmembrane protease serine 2 enzyme used by SARS-CoV-2 for cell entry. Morpeth et al report the results of an open-label randomized clinical trial of nafamostat for noncritically ill patients with Covid-19.

Identifiants

DOI: 10.1056/EVIDoa2300132 PMID: 38320527
pubmed: 38320527
doi: 10.1056/EVIDoa2300132
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

EVIDoa2300132

Auteurs

Susan C Morpeth (SC)

Department of Microbiology and Infectious Diseases, Middlemore Hospital, Te Whatu Ora Counties Makukau, Auckland, New Zealand.
Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Balasubramanian Venkatesh (B)

Department of Intensive Care Medicine, The University of Queensland at Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Department of Intensive Care Medicine, The University of Queensland at The Wesley Hospital, Toowong, QLD, Australia.
The George Institute for Global Health, Newtown, NSW, Australia.

James A Totterdell (JA)

Faculty of Medicine and Health, The University of Sydney School of Public Health, Sydney.

Grace M McPhee (GM)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Robert K Mahar (RK)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, VIC, Australia.

Mark Jones (M)

Department of Health and Clinical Analytics, The University of Sydney School of Public Health, Sydney.

Methma Bandara (M)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Lauren A Barina (LA)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Bhupendra K Basnet (BK)

Department of Medicine, Bir Hospital, Kathmandu, Nepal.
Department of Infectious Diseases, Perth Children's Hospital, Perth, WA, Australia.

Asha C Bowen (AC)

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA, Australia.

Andrew J Burke (AJ)

Faculty of Medicine, The University of Queensland, Herston, QLD, Australia.
Department of Infectious Diseases, Prince Charles Hospital, Merthyr Tydfil, United Kingdom.

Belinda Cochrane (B)

Department of Respiratory and Sleep Medicine, Campbelltown Hospital, Campbelltown, NSW, Australia.
Western Sydney University School of Medicine, Campbelltown, NSW, Australia.

Justin T Denholm (JT)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, VIC, Australia.

Ashesh Dhungana (A)

Department of Medicine, National Academy of Medical Sciences at Bir Hospital, Kathmandu, Nepal.

Gregory J Dore (GJ)

Viral Hepatitis Clinical Research Program, Kirby Institute, University of New South Wales, Kensington, NSW, Australia.
Department of Infectious Diseases, St. Vincent's Hospital, Melbourne, VIC, Australia.

Ravindra Dotel (R)

Department of Infectious Diseases, Blacktown Hospital, Blacktown, NSW, Australia.

Eamon Duffy (E)

Department of Infectious Diseases, Te Whatu Ora Health New Zealand at Auckland City Hospital, Auckland, New Zealand.
School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Jack Dummer (J)

Department of Medicine, University of Otago, Dunedin, New Zealand.
Respiratory Services, Dunedin Hospital, Dunedin, New Zealand.

Hong Foo (H)

Department of Microbiology and Infectious Diseases, NSW Health Pathology Liverpool, Liverpool, NSW, Australia.

Timothy L Gilbey (TL)

Department of Medicine and Infectious Diseases, Wagga Wagga Base Hospital, Wagga Wagga, Australia.

Naomi E Hammond (NE)

Critical Care Program, The George Institute for Global Health, New Town, NSW, Australia.
Critical Care Program, The University of New South Wales, Sydney.
Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St. Leonards, NSW, Australia.

Bernard J Hudson (BJ)

Department of Microbiology and Infectious Diseases, NSW Health Pathology, St. Leonards, St. Leonards, NSW, Australia.

Vivekanand Jha (V)

The George Institute for Global Health, Newtown, NSW, Australia.

Purnima R Jevaji (PR)

Department of Research, The George Institute for Global Health, Pune, Maharashta, India.

Oommen John (O)

Department of Research, The George Institute for Global Health, Vellore, India.
Prasanna School of Public Health, Manipal Academy of Higher Education, Karnataka, India.

Rajesh Joshi (R)

Department of Research, The George Institute for Global Health, Pune, Maharashta, India.

Gagandeep Kang (G)

Wellcome Trust Research Laboratory, Chartered Accountants Australia and New Zealand, Sydney.

Baldeep Kaur (B)

Critical Care Program, The George Institute for Global Health, New Town, NSW, Australia.

Seungtaek Kim (S)

Zoonotic Virus Laboratory, Institut Pasteur Korea, Bundang-gu, Gyeonggi-do, Republic of Korea.

Santa Kumar Das (SK)

Department of Internal Medicine, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Nepal.

Jillian S Y Lau (JSY)

Department of Infectious Diseases, Eastern Health, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Roberta Littleford (R)

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Queensland, QLD, Australia.

Julie A Marsh (JA)

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA, Australia.
Centre for Child Health Research, University of Western Australia Medical School, Nedlands, WA, Australia.

Ian C Marschner (IC)

NHMRC Clinical Trials Centre, Faculty of Medicine and Health, The University of Sydney, Sydney.

Gail Matthews (G)

Department of Infectious Diseases, St. Vincent's Hospital Sydney, Sydney.
Therapeutic and Vaccine Research Program, The Kirby Institute at The University of New South Wales, Kensington, NSW, Australia.

Michael J Maze (MJ)

Department of Medicine, University of Otago Christchurch, Christchurch, New England.

Colin J McArthur (CJ)

Department of Critical Care Medicine, Te Whatu Ora - Health New Zealand, Wellington, New Zealand.

James D McFadyen (JD)

Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia.
Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

James H McMahon (JH)

Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, VIC, Australia.

Zoe K McQuilten (ZK)

Department of Haematology, Monash Health, Melbourne, VIC, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

James Molton (J)

Department of Infectious Diseases, Western Health, Footscray, VIC, Australia.

Jocelyn M Mora (JM)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Vijaybabu Mudaliar (V)

Department of Research, The George Institute for Global Health, Pune, Maharashta, India.

Vi Nguyen (V)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Matthew V N O'Sullivan (MVN)

Department of Microbiology and Infectious Diseases, NSW Health Pathology Westmead Hospital, Newcastle, NSW, Australia.
Faculty of Medicine and Health, University of Sydney Westmead Clinical School, Sydney.

Suman Pant (S)

Department of Internal Medicine, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Nepal.

Jaha E Park (JE)

Business Development Team, Chong Kun Dang Pharmaceutical Corp., Dongbaekjukjeon-daero, Giheung-gu Yongin, Kyeonggi-do, Republic of Korea.

David L Paterson (DL)

Saw Swee Hock School of Public Health, National Institute of Singapore, Singapore.

David J Price (DJ)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.

Nigel Raymond (N)

Department of Medicine, Te Whatu Ora Health New Zealand Capital, Coast and Hutt Valley, Wellington, New Zealand.
Department of Medicine, Wellington School of Medicine, University of Otago, Wellington, New Zealand.

Megan A Rees (MA)

Department of Respiratory and Sleep Medicine, The Royal Melbourne Hospital, Melbourne, VIC, Australia.

James O Robinson (JO)

Department of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia.
Department of Microbiology, PathWest Laboratory Medicine, Nedlands, WA, Australia.

Benjamin A Rogers (BA)

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
Department of Infectious Diseases, Monash Health, Clayton, VIC, Australia.

Wang-Shick Ryu (WS)

Virology, Institute Pasteur Korea, Bundang-gu, Gyeonggi-do, Republic of Korea.

Joe Sasadeusz (J)

Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, VIC, Australia.

Omar Shum (O)

Department of Infectious Diseases, Wollongong Hospital, Kingoonya, NSW, Australia.
Graduate School of Medicine, University of Wollongong, Wollonngong, NSW, Australia.

Thomas L Snelling (TL)

Faculty of Medicine and Health, The University of Sydney School of Public Health, Sydney.
Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Nedlands, WA, Australia.

Christine Sommerville (C)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Nanette Trask (N)

Chartered Accountants Australia and New Zealand, Sydney.

Sharon R Lewin (SR)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, VIC, Australia.

Thomas E Hills (TE)

Department of Clinical Research, Medical Research Institute of New Zealand, Wellington, New Zealand.
Department of Infectious Diseases, Auckland City Hospital, Auckland, New Zealand.

Joshua S Davis (JS)

School of Medicine and Public Health, The University of Newcastle, New Castle, Australia.
Global and Tropical Health Division, Menzies School of Health Research, Darwin, NT, Australia.

Jason A Roberts (JA)

Faculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
Metro North Health, Herston Infectious Diseases Institute, Herston, QLD, Australia.
Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.
Division of Anaesthesiology, Critical Care Emergency and Pain Medicine, Nîmes University Hospital at The University of Montpellier, Nîmes, France.

Steven Y C Tong (SYC)

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, VIC, Australia.

Classifications MeSH