Effects of intranasal and intramuscular administration of butorphanol and zolazepam-tiletamine combination on intraocular pressure and tear secretion in New Zealand White rabbits.
Schirmer
eye pressure
nasal
ocular
sedation
tear production
Journal
Veterinary ophthalmology
ISSN: 1463-5224
Titre abrégé: Vet Ophthalmol
Pays: England
ID NLM: 100887377
Informations de publication
Date de publication:
06 Feb 2024
06 Feb 2024
Historique:
revised:
02
12
2023
received:
21
08
2023
accepted:
17
01
2024
medline:
7
2
2024
pubmed:
7
2
2024
entrez:
7
2
2024
Statut:
aheadofprint
Résumé
This study aimed to compare the effect of intranasal (IN) and intramuscular (IM) administration of butorphanol and zolazepam-tiletamine (ZT) combination on intraocular pressure (IOP) and tear secretion (TS) in rabbits. Fourteen healthy male New Zealand White rabbits weighing 3.05 ± 0.72 kg, aged between 1 and 2 years old, were included in the study. Animals randomly received 0.5 mg/kg butorphanol and 15 mg/kg ZT combination either with IN or IM administration. IOP and TS were measured at baseline (T0), and followed by 5, 15, 30, 45, and 60 min after drug administration. The sedation variables, the time to onset of sedation, duration of sedation, and sedation scores were also recorded. The route of administration for the butorphanol and ZT combination had no significant effect on the mean IOP (p = .301) and TS (p = .445). Furthermore, there were no significant changes observed in the IOP (p = .472) and TS (p = .348) over time. The time to onset of sedation was earlier in the IN group (4.57 ± 0.79 min) than in the IM group (5.86 ± 0.9 min; p = .0004). The duration of sedation was significantly longer for IM (57.43 ± 3.41 min) compared with IN (45.0 ± 1.91 min; p < .0001). No significant difference in the sedation score was observed between groups at all time points. In conclusion, both IN and IM administration of the butorphanol and ZT combination in rabbits had similar effects on IOP and TS.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 American College of Veterinary Ophthalmologists.
Références
Featherstone HJ, Heinrich CL. Ophthalmic examination and diagnostics part 1: the eye examination and diagnostic procedures. In: Gelatt KN, ed. Veterinary Ophthalmology. 5th ed. John Wiley & Sons Inc.; 2013:533-613.
Gelatt KN. Eye examination and diagnostics. In: Gelatt KN, ed. Essentials of Veterinary Ophthalmology. 3rd ed. John Wiley & Sons; 2014:101-144.
Robertson S. Anesthetic protocols for dogs and cats. In: White S, ed. High-Quality, High-Volume Spay and Neuter and Other Shelter Surgerie. 1st ed. Wiley-Blackwell; 2020:153-192.
Yanmaz LE, Okur S, Ersoz U, Senocak MG, Golgeli A. Comparison of intratesticular and intramuscular administration of zolazepam-tiletamine combination on sedation, induction, and recovery qualities and vital variables in cats undergoing castration: a prospective, randomized, clinical study. Vet Res Commun. 2022;46(4):1349-1353. doi:10.1007/s11259-022-09993-6
Topal A, Gul Satar NY, Ates O, Uckan EM, Yavas O, Cangul IT. Comparison of the effects of ketamine-diazepam, tiletamine-zolazepam and propofol infusion anesthesia in rabbits. Kafkas Univ Vet Fak Derg. 2023;29(2):134-144. doi:10.9775/kvfd.2022.28744
Portnoy LG, Hustead DR. Pharmacokinetics of butorphanol tartrate in rabbits. Am J Vet Res. 1992;53(4):541-543.
Okur S, Yanmaz LE, Golgeli A, et al. Sedative and cardiopulmonary effects of intranasal butorphanol with midazolam or dexmedetomidine in New Zealand white rabbits. Vet Rec. 2023;193:e2999. doi:10.1002/vetr.2999
Santangelo B, Micieli F, Mozzillo T, et al. Transnasal administration of a combination of dexmedetomidine, midazolam and butorphanol produces deep sedation in New Zealand white rabbits. Vet Anaesth Analg. 2016;43(2):209-214. doi:10.1111/vaa.12278
Vlerick L, Devreese M, Peremans K, et al. Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs. PloS One. 2020;15(1):e0227762. doi:10.1371/journal.pone.0227762
Mauthe von Degerfeld M, Serpieri M, Bonaffini G, Ottino C, Quaranta G. Intranasal atomization of ketamine, medetomidine and butorphanol in pet rabbits using a mucosal atomization device. Animals. 2023;13(13):2076. doi:10.3390/ani13132076
Usach I, Martinez R, Festini T, Peris JE. Subcutaneous injection of drugs: literature review of factors influencing pain sensation at the injection site. Adv Ther. 2019;36:2986-2996. doi:10.1007/s12325-019-01101-6
Wijnants D, Stalmans I, Vandewalle E. The effects of intranasal, inhaled and systemic glucocorticoids on intraocular pressure: a literature review. J Clin Med. 2022;11(7):2007. doi:10.3390/jcm11072007
Raekallio M, Ansah OB, Kuusela E, Vainio O. Some factors influencing the level of clinical sedation induced by medetomidine in rabbits. J Vet Pharmacol Ther. 2002;25(1):39-42. doi:10.1046/j.1365-2885.2002.00382.x
Kovalcuka L, Nikolajenko M. Changes in intraocular pressure, horizontal pupil diameter, and tear production during the use of topical 1% cyclopentolate in cats and rabbits. Open Vet J. 2020;10(1):59-67. doi:10.4314/ovj.v10i1.10
Yanmaz LE, Dogan E, Okur S, Okumus Z, Ersoz U. Comparison of the effects of intranasal and intramuscular administrations of zolazepam-tiletamine combination on intraocular pressure in cats. Vet Ophthalmol. 2016;19:115-118. doi:10.1111/vop.12400
Mattos Junior ED, Cunha OD, Barros LFM, et al. Dissociative anesthetic combination reduces intraocular pressure (IOP) in rabbits. Semina Ciênc Agrár. 2014;35(2):905-909. doi:10.5433/1679-0359.2014v35n2p905
Douet JY, Regnier A, Dongay A, Jugant S, Jourdan G, Concordet D. Effect of sedation with butorphanol on variables pertaining to the ophthalmic examination in dogs. Vet Ophthalmol. 2018;21(5):452-458. doi:10.1111/vop.12530
Okur S, Yanmaz L, Senocak M, et al. Comparison of intraocular pressure in New Zealand white rabbits measured using rebound and applanation tonometers and four different methods of physical restraint. N Z Vet J. 2023;71(5):251-258.
Takenaka J, Mochizuki H, Kunihara E, Tanaka J, Kiuchi Y. Evaluation of rebound tonometer for measuring intraocular pressure at deviated angle and position. Curr Eye Res. 2011;36(5):422-428.
Erol M, Erol H, Atalan G, Doğan Z, Yönez MK, Melek Ș. Effects of systemically used midazolam, ketamine and isoflurane anesthetic agents on intraocular pressure and tear production in rabbits. Harran Üniv Vet Fak Derg. 2018;7(1):21-25. doi:10.31196/huvfd.458783
Meyer R, Fish R. Pharmacology of injectable anesthetics, sedatives, and tranquilizers. In: Fish R, Danneman PJ, Brown M, Karas A, eds. Anesthesia and Analgesia in Laboratory Animals. 2nd ed. Academic Press; 2008:27-82.
Karasu A, Altug N, Aslan L, Bakir B, Yüksek N. Evaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits. Med Weter. 2018;74(10):646-652. doi:10.21521/mw.6119
Wilson RP, Zagon IS, Larach DR, Lang CM. Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol. Pharmacol Biochem Behav. 1992;43(4):1129-1133. doi:10.1016/0091-3057(92)90492-x
Yanmaz LE, Okur S, Turgut F, Golgeli A. Effects of intramuscular and intranasal administration of midazolam- dexmedetomidine on sedation and some cardiopulmonary variables in New Zealand white rabbits. Vet Anaesth Analg. 2022;49(1):113-117. doi:10.1016/j.vaa.2021.10.003
Yanmaz LE, Doğan E, Okumuş Z, Şenocak MG, Ersoz U, Okur S. Comparison of intranasal and intramuscular administration of zolazepam tiletamine combination in cats. Atatürk Üniversitesi Vet Bil Derg. 2017;12(2):124-129. doi:10.17094/ataunivbd.347957
Fortuna A, Alves G, Serralheiro A, Sousa J, Falcão A. Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules. Eur J Pharm Biopharm. 2014;88(1):8-27. doi:10.1016/j.ejpb.2014.03.004
Trevino J, Quispe R, Khan F, Novak V. Non-invasive strategies for nose-to-brain drug delivery. J Clin Trials. 2020;10(7):439.