Role of Gabapentin in Traumatic Brain Injury: A Prospective Comparative Study.

Background

Traumatic brain injury (TBI) is a major cause of mortality among young individuals, accounting for 65% of deaths in road traffic accidents. Paroxysmal sympathetic hyperactivity (PSH) is a common syndrome associated with TBI. This study represents the first prospective investigation aimed at assessing the impact of gabapentin on TBI patients, focusing on the prevention of secondary brain injury and brain edema while enhancing the Glasgow Coma Scale (GCS).

Materials and methods

The study was conducted from September 2019 to July 2021 after receiving ethical committee approval. It included adult ICU patients (≥18 years) with moderate and severe GCS. Patients below 18 years, death within 48 hours, non-consenting, pregnant females, and individuals allergic to gabapentin were excluded from the study. Patients were randomly allocated in two groups: study group received 300 mg of gabapentin orally twice daily and control group received multivitamin tablets twice daily. The treatment period spanned 2 weeks. Follow-up occurred in the ICU and continued for up to 3 months post-discharge, including telephonic conversations.

Results

About 60 patients were involved for analysis. Significant differences were found in GCS change from admission to discharge, Glasgow Outcome Scale (GOS) at 30 and 90 days, PSH episodes, and sedation bolus per day. Glasgow Coma Scale change was 53% in the study group compared with 25% in the control group (

Conclusion

This pioneering study underscores the potential of gabapentin in managing traumatic brain injuries.

How to cite this article

Singh R, Ambasta S, Bais PS, Azim A, Kumar S, Upreti B,

Informations de copyright

Copyright © 2024; The Author(s).

Déclaration de conflit d'intérêts

Source of support: Nil Conflict of interest: None Patient consent statement: The author(s) have obtained informed consent. All patient information has been de-identified to protect the patient privacy.