Long-term clinical outcomes of patients with sympathetic ophthalmia.

Dalen-Fuchs nodules Granulomatous uveitis Ocular trauma Sympathetic ophthalmia

Journal

International ophthalmology

ISSN: 1573-2630

Titre abrégé: Int Ophthalmol

Pays: Netherlands

ID NLM: 7904294

Informations de publication

Date de publication:
07 Feb 2024

Historique:

received: 27 08 2023

accepted: 19 10 2023

medline: 7 2 2024

pubmed: 7 2 2024

entrez: 7 2 2024

Statut: epublish

Résumé

To present the long-term clinical outcomes of patients with sympathetic ophthalmia (SO). Retrospective review of patients' medical files between 2002 and 2022. Included were seven patients (four males). The mean ± SD age at presentation was 37.9 ± 22.5 years. Four patients had co-morbidities: three had diabetes mellitus type 2 and one had Turner Syndrome. Trauma was the inciting event in six patients and postoperative endophthalmitis in one patient. Decreased visual acuity (VA) was the leading symptom in the sympathizing eye and all of the patients presented with panuveitis. The mean ± SD interval between the triggering incident and the onset of SO in six cases was 4.3 ± 4.2 months. One case presented 30 years following the eye injury. Five patients underwent enucleation/evisceration of the exciting eye. The mean ± SD presenting LogMAR BCVA in the sympathizing eye was 0.57 ± 0.82, and the final LogMAR BCVA was 0.61 ± 0.95. Inflammation was completely controlled in 5 patients at a mean ± SD of 8.55 ± 9.21 months following the institution of immunomodulatory therapy, and it was partially controlled in 2 patients. VA deteriorated in all 3 diabetic patients and improved or remained stable in the 4 young and healthy patients. The mean ± SD follow-up period after achieving drug-free remission was 28 ± 22.8 months. The mean ± SD follow-up time was 6.8 ± 5.6 years. SO is one of the most sight-threatening conditions, affecting the healthy eye. In this cohort, the favorable visual outcome was especially seen in young and healthy individuals. Visual prognosis is directly related to prompt diagnosis and treatment.

Identifiants

DOI: 10.1007/s10792-024-03007-x PMID: 38324101

pubmed: 38324101

doi: 10.1007/s10792-024-03007-x

pii: 10.1007/s10792-024-03007-x

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

Informations de copyright

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