Neurovascular Complications of Iatrogenic

Journal

The New England journal of medicine

ISSN: 1533-4406

Titre abrégé: N Engl J Med

Pays: United States

ID NLM: 0255562

Informations de publication

Date de publication:
08 Feb 2024

Historique:

medline: 7 2 2024

pubmed: 7 2 2024

entrez: 7 2 2024

Statut: ppublish

Résumé

A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with symptoms after a median delay of 39 days.

Identifiants

DOI: 10.1056/NEJMoa2308192 PMID: 38324485

pubmed: 38324485

doi: 10.1056/NEJMoa2308192

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

522-529

Informations de copyright

Copyright © 2024 Massachusetts Medical Society.

Auteurs

Nora Strong (N)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

ORCID: 0000-0003-0540-2124

Grant Meeks (G)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Sunil A Sheth (SA)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Louise McCullough (L)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Julian A Villalba (JA)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Chunfeng Tan (C)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Andrew Barreto (A)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Audrey Wanger (A)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Michelle McDonald (M)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Peter Kan (P)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Hashem Shaltoni (H)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Jose Campo Maldonado (J)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Victoria Parada (V)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Ameer E Hassan (AE)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Sarah Reagan-Steiner (S)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Tom Chiller (T)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Jeremy A W Gold (JAW)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

Dallas J Smith (DJ)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

ORCID: 0000-0001-5707-528X

Luis Ostrosky-Zeichner (L)

From McGovern Medical School, University of Texas Health Science Center at Houston, Houston (N.S., G.M., S.A.S., L.M., C.T., A.B., A.W., M.M., L.O.-Z.), the University of Texas Medical Branch, Galveston (P.K., H.S.), and the University of Texas Rio Grande Valley-Harlingen, Harlingen (J.C.M., V.P., A.E.H.) - all in Texas; and the Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (J.A.V., S.R.-S.), and the Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases (T.C., J.A.W.G., D.J.S.), Centers for Disease Control and Prevention, Atlanta.

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