Mitochondrial function in peripheral blood cells across the human lifespan.
Journal
npj aging
ISSN: 2731-6068
Titre abrégé: NPJ Aging
Pays: England
ID NLM: 9918402285106676
Informations de publication
Date de publication:
07 Feb 2024
07 Feb 2024
Historique:
received:
15
06
2023
accepted:
20
11
2023
medline:
8
2
2024
pubmed:
8
2
2024
entrez:
7
2
2024
Statut:
epublish
Résumé
Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been demonstrated in human muscle tissue. A handful of studies have examined age-related mitochondrial dysfunction in human blood cells, and only with small sample sizes and mainly in platelets. In this study, we analyzed mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and platelets from 308 individuals across the human lifespan (0-86 years). In regression analyses, with adjustment for false discovery rate (FDR), we found age-related changes in respiratory measurements to be either small or absent. The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs. These results add to the understanding of mitochondrial dysfunction in aging and to its possible role in immune cell and platelet senescence.
Identifiants
pubmed: 38326348
doi: 10.1038/s41514-023-00130-4
pii: 10.1038/s41514-023-00130-4
doi:
Types de publication
Journal Article
Langues
eng
Pagination
10Informations de copyright
© 2024. The Author(s).
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