Clinical and molecular study of radiation-induced gliomas.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 Feb 2024
07 Feb 2024
Historique:
received:
20
10
2023
accepted:
31
01
2024
medline:
8
2
2024
pubmed:
8
2
2024
entrez:
7
2
2024
Statut:
epublish
Résumé
In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk assessment for developing gliomas. A cohort of 12 patients who developed RIG 9.5 years (3-31 years) after previous cranial radiotherapy for brain tumors or T-cell acute lymphoblastic leukemia was established. The derived risk of RIG development based on our consecutive cohort of 371 irradiated patients was 1.6% at 10 years and 3.02% at 15 years. Patients with RIG glioma had a dismal prognosis with a median survival of 7.3 months. We described radiology features that might indicate the suspicion of RIG rather than the primary tumor recurrence. Typical molecular features identified by molecular biology examination included the absence of Histon3 mutation, methylation profile of pedHGG-RTK1 and the presence of recurrent PDGFRA amplification and CDKN2A/B deletion. Of the two long-term surviving patients, one had gliomatosis cerebri, and the other had pleomorphic xanthoastrocytoma with BRAF V600E mutation. In summary, our experience highlights the need for tissue diagnostics to allow detailed molecular biological characterization of the tumor, differentiation of the secondary tumor from the recurrence of the primary disease and potentially finding a therapeutic target.
Identifiants
pubmed: 38326438
doi: 10.1038/s41598-024-53434-0
pii: 10.1038/s41598-024-53434-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3118Subventions
Organisme : Grantová Agentura, Univerzita Karlova
ID : 204220
Organisme : Grantová Agentura, Univerzita Karlova
ID : PRIMUS/19/MED/06
Organisme : European Union
ID : LX22NPO5102
Organisme : University Hospital Motol
ID : MH CZ-DRO,00064203
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NU21-07-00419
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NU23-08-00460
Informations de copyright
© 2024. The Author(s).
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