Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.

Biochemistry Immunology Structural biology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
16 Feb 2024
Historique:
received: 08 09 2023
revised: 02 11 2023
accepted: 16 01 2024
medline: 8 2 2024
pubmed: 8 2 2024
entrez: 8 2 2024
Statut: epublish

Résumé

Coronavirus nucleocapsid protein (NP) of SARS-CoV-2 plays a central role in many functions important for virus proliferation including packaging and protecting genomic RNA. The protein shares sequence, structure, and architecture with nucleocapsid proteins from betacoronaviruses. The N-terminal domain (NP

Identifiants

DOI: 10.1016/j.isci.2024.108976 PMID: 38327783 PMC: PMC10847736
pubmed: 38327783
doi: 10.1016/j.isci.2024.108976
pii: S2589-0042(24)00197-4
pmc: PMC10847736
doi:

Types de publication

Journal Article

Langues

eng

Pagination

108976

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Youngchang Kim (Y)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Natalia Maltseva (N)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Christine Tesar (C)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Robert Jedrzejczak (R)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Michael Endres (M)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Heng Ma (H)

Data Science and Learning Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Haley L Dugan (HL)

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Christopher T Stamper (CT)

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Changsoo Chang (C)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Lei Li (L)

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Siriruk Changrob (S)

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Nai-Ying Zheng (NY)

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Min Huang (M)

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Arvind Ramanathan (A)

Data Science and Learning Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Patrick Wilson (P)

Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10021, USA.

Karolina Michalska (K)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Andrzej Joachimiak (A)

Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.

Classifications MeSH