Biochemistry of the hypoxia-inducible factor hydroxylases.
Ankyrin repeat domain
Asparaginyl hydroxylase
Epigenetics
Factor inhibiting HIF (FIH)
HIF prolyl-hydroxylases (PHDs/EGLNs)
Hypoxia-inducible factor (HIF)
JmjC demethylases
JmjC histone demethylases (JmjC KDMs)
Oxygen/hypoxia sensing
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
02
11
2023
revised:
11
01
2024
accepted:
11
01
2024
pubmed:
9
2
2024
medline:
9
2
2024
entrez:
8
2
2024
Statut:
ppublish
Résumé
The hypoxia-inducible factors are α,β-heterodimeric transcription factors that mediate the chronic response to hypoxia in humans and other animals. Protein hydroxylases belonging to two different structural subfamilies of the Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase superfamily modify HIFα. HIFα prolyl-hydroxylation, as catalysed by the PHDs, regulates HIFα levels and, consequently, α,β-HIF levels. HIFα asparaginyl-hydroxylation, as catalysed by factor inhibiting HIF (FIH), regulates the transcriptional activity of α,β-HIF. The activities of the PHDs and FIH are regulated by O
Identifiants
pubmed: 38330792
pii: S1367-5931(24)00004-8
doi: 10.1016/j.cbpa.2024.102428
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102428Informations de copyright
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.