Involvement of expanded cytotoxic and proinflammatory CD28

Humans Aged T-Lymphocytes / metabolism CD28 Antigens Sjogren's Syndrome / genetics Salivary Glands, Minor / metabolism Antineoplastic Agents
CD28(null) T CXCR3-CXCL9/10 axis Costimulation pSS

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
Apr 2024
Historique:
received: 30 10 2023
revised: 13 01 2024
accepted: 03 02 2024
medline: 18 3 2024
pubmed: 9 2 2024
entrez: 8 2 2024
Statut: ppublish

Résumé

The absence of CD28 is a feature of antigen-experienced, highly differentiated and aged T cells. The pathogenicity of CD28 pSS patients and paired healthy controls (HCs) were enrolled. The phenotype of peripheral CD28 A significant expansion of peripheral CD28 Increasing CD28

Identifiants

DOI: 10.1016/j.clim.2024.109927 PMID: 38331302
pubmed: 38331302
pii: S1521-6616(24)00038-X
doi: 10.1016/j.clim.2024.109927
pii:
doi:

Substances chimiques

CD28 Antigens 0
Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109927

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declared no conflict of interest.

Auteurs

Chuiwen Deng (C)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China.

Anqi Wang (A)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China.

Wenli Li (W)

Department of Rheumatology, Key Myositis Laboratories, China-Japan Friendship Hospital, Beijing, China.

Lidan Zhao (L)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China.

Jiaxin Zhou (J)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China.

Wen Zhang (W)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China.

Mengtao Li (M)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China.

Yunyun Fei (Y)

Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education, Beijing, China; Department of Health Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. Electronic address: feiyunyun@pumch.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Involvement of expanded cytotoxic and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Involvement of expanded cytotoxic and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Involvement of expanded cytotoxic and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CD28 › Involvement of expanded cytotoxic and...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Syndrome de Gougerot-Sjögren › Involvement of expanded cytotoxic and...
questionsmedicales.fr › Système stomatognathique › Bouche › Glandes salivaires › Glandes salivaires mineures › Involvement of expanded cytotoxic and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Involvement of expanded cytotoxic and...