Asthma and rhinitis control in adolescents and young adults: A real-world MASK-air study.

adherence adolescents allergic rhinitis asthma digital health mHealth real-world data

Journal

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718

Informations de publication

Date de publication:
Feb 2024
Historique:
revised: 10 01 2024
received: 31 10 2023
accepted: 15 01 2024
medline: 9 2 2024
pubmed: 9 2 2024
entrez: 9 2 2024
Statut: ppublish

Résumé

In allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication adherence. In a cross-sectional study (2015-2022), we assessed European users of the MASK-air mHealth app of three age groups: adolescents (13-18 years), young adults (18-26 years), and adults (>26 years). We compared them on their reported rhinitis and asthma symptoms, use and adherence to rhinitis and asthma treatment and app adherence. Allergy symptoms and control were assessed by means of visual analogue scales (VASs) on rhinitis or asthma, the combined symptom-medication score (CSMS), and the electronic daily control score for asthma (e-DASTHMA). We built multivariable regression models to compare symptoms or medication accounting for potential differences in demographic characteristics and baseline severity. We assessed 965 adolescent users (15,252 days), 4595 young adults (58,161 days), and 15,154 adult users (258,796 days). Users of all three age groups displayed similar app adherence. In multivariable models, age groups were not found to significantly differ in their adherence to rhinitis or asthma medication. These models also found that adolescents reported lower VAS on global allergy, ocular, and asthma symptoms (as well as lower CSMS) than young adults and adults. Adolescents reported a better rhinitis and asthma control than young adults and adults, even though similar medication adherence levels were observed across age groups. These results pave the way for future studies on understanding how adolescents control their allergic diseases.

Sections du résumé

BACKGROUND BACKGROUND
In allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication adherence.
METHODS METHODS
In a cross-sectional study (2015-2022), we assessed European users of the MASK-air mHealth app of three age groups: adolescents (13-18 years), young adults (18-26 years), and adults (>26 years). We compared them on their reported rhinitis and asthma symptoms, use and adherence to rhinitis and asthma treatment and app adherence. Allergy symptoms and control were assessed by means of visual analogue scales (VASs) on rhinitis or asthma, the combined symptom-medication score (CSMS), and the electronic daily control score for asthma (e-DASTHMA). We built multivariable regression models to compare symptoms or medication accounting for potential differences in demographic characteristics and baseline severity.
RESULTS RESULTS
We assessed 965 adolescent users (15,252 days), 4595 young adults (58,161 days), and 15,154 adult users (258,796 days). Users of all three age groups displayed similar app adherence. In multivariable models, age groups were not found to significantly differ in their adherence to rhinitis or asthma medication. These models also found that adolescents reported lower VAS on global allergy, ocular, and asthma symptoms (as well as lower CSMS) than young adults and adults.
CONCLUSIONS CONCLUSIONS
Adolescents reported a better rhinitis and asthma control than young adults and adults, even though similar medication adherence levels were observed across age groups. These results pave the way for future studies on understanding how adolescents control their allergic diseases.

Identifiants

DOI: 10.1111/pai.14080 PMID: 38334246
pubmed: 38334246
doi: 10.1111/pai.14080
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14080

Informations de copyright

© 2024 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Références

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Auteurs

Bernardo Sousa-Pinto (B)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.

Arunas Valiulis (A)

Interdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
European Academy of Paediatrics, (EAP/UEMS-SP), Brussels, Belgium.

Erik Melén (E)

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
ORCID: 0000-0002-8248-0663

Gerard H Koppelman (GH)

Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, GRIACResearch Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Nikolaos G Papadopoulos (NG)

Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.

Mika Makela (M)

Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.

Tari Haahtela (T)

Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.

Matteo Bonini (M)

Department of Cardiovascular and Respiratory Sciences, Universita Cattolica del Sacro Cuore, Rome, Italy.
Department of Neurological, ENT and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli - IRCCS, Rome, Italy.
National Heart and Lung Institute (NHLI), Imperial College London, London, UK.

Fulvio Braido (F)

Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Luisa Brussino (L)

Department of Medical Sciences, University of Torino, Torino, Italy.
Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy.

Alvaro A Cruz (AA)

Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil.

Alessandro Fiocchi (A)

Allergy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
ORCID: 0000-0002-2549-0523

Mattia Giovannini (M)

Allergy Unit, Meyer Children's Hospital, IRCCS, Florence, Italy.
Department of Health Sciences, University of Florence, Florence, Italy.
ORCID: 0000-0001-9568-6882

Bilun Gemicioglu (B)

Department of Pulmonary Diseases, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Marek Kulus (M)

Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland.

Piotr Kuna (P)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Maciej Kupczyk (M)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Violeta Kvedariene (V)

Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Désirée E Larenas-Linnemann (DE)

Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
ORCID: 0000-0002-5713-5331

Renaud Louis (R)

Department of Pulmonary Medicine, CHU Liège, Liège, Belgium.
GIGA I3 Research Group, University of Liège, Liège, Belgium.

Mario Morais-Almeida (M)

Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.

Marek Niedoszytko (M)

Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.

Markus Ollert (M)

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
ORCID: 0000-0002-8055-0103

Oliver Pfaar (O)

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
ORCID: 0000-0003-4374-9639

Frederico S Regateiro (FS)

Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
ORCID: 0000-0002-6332-3056

Graham Roberts (G)

Faculty of Medicine, University of Southampton, Southampton, UK.
The David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK.
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
ORCID: 0000-0003-2252-1248

Boleslaw Samolinski (B)

Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.

Marine Savouré (M)

Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Villejuif, France.
Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.

Luis Taborda-Barata (L)

UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
ORCID: 0000-0001-6649-8890

Sanna Toppila-Salmi (S)

Department of Otorhinolaryngology, Kuopio University Hospital and University of Eastern Finland, Kupio, Finland.
Department of Allergy, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Maria Teresa Ventura (MT)

Allergy and Clinical Immunology, University of Bari Medical School, Bari, Italy.
Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy.

Marta Vazquez-Ortiz (M)

Section of Inflammation, Repair and Development, Imperial College London, National Heart and Lung Institute, London, UK.
Department of Paediatrics, Imperial College Healthcare NHS Trust, London, UK.

Rafael José Vieira (RJ)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.

Joao A Fonseca (JA)

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.

Arzu Yorgancioglu (A)

Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.

Torsten Zuberbier (T)

Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.

Josep M Anto (JM)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Jean Bousquet (J)

Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
MASK-air, Montpellier, France.
ORCID: 0000-0002-4061-4766

Nhân Pham-Thi (N)

Ecole Polytechnique de Palaiseau, Palaiseau, France.
IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France.
Université Paris Cité, Paris, France.

Classifications MeSH