[Intraoperative stimulated Raman histology for personalized brain tumor surgery].

Personalisierte Hirntumorchirurgie mittels intraoperativer stimulierter Raman-Histologie.

Artificial intelligence Intraoperative tissue analysis Personalized surgery Raman spectroscopy Rapid frozen section diagnostics

Journal

Chirurgie (Heidelberg, Germany)

ISSN: 2731-698X

Titre abrégé: Chirurgie (Heidelb)

Pays: Germany

ID NLM: 9918383081906676

Informations de publication

Date de publication:
Apr 2024

Historique:

accepted: 11 01 2024

pubmed: 9 2 2024

medline: 9 2 2024

entrez: 9 2 2024

Statut: ppublish

Résumé

In brain tumor surgery a personalized surgical approach is crucial to achieve a maximum safe tumor resection. The extent of resection decisively depends on the histological diagnosis. Stimulated Raman histology (SRH), a fiber laser-based optical imaging method, offers the possibility for evaluation of an intraoperative diagnosis in a few minutes. To provide an overview on the applications of SRH in neurosurgery and transference of the technique to other surgical disciplines. Description of the technique and review of the current literature on SRH. The SRH technique was successfully used in multiple neuro-oncological tumor entities. Initial pilot projects showed the potential for analysis of extracranial tumors. The use of SRH provides a near real-time diagnosis with high diagnostic accuracy and provides further developmental potential to improve personalized tumor surgery. HINTERGRUND: Ein individualisiertes chirurgisches Vorgehen ist in der Hirntumorchirurgie zum Erreichen einer maximal sicheren Resektion essenziell. Die Radikalität der Resektion ist maßgeblich abhängig von der histologischen Diagnose. Die stimulierte Raman-Histologie (SRH), eine laserbasierte optische Bildgebung, bietet die Möglichkeit der Erhebung einer intraoperativen Diagnose in wenigen Minuten. Überblick über die Anwendung von SRH in der Neurochirurgie und Übertragung der Technik auf weitere chirurgische Disziplinen. Beschreibung der Technik und Zusammenfassung der aktuellen Literatur zu SRH. SRH konnte erfolgreich bei multiplen neuroonkologischen Tumorentitäten angewendet werden. Erste Pilotprojekte zeigen Potenzial zur Analyse extrazerebraler Tumoren auf. SRH ermöglicht eine Echtzeitdiagnose mit hoher diagnostischer Genauigkeit und bietet weiteres Entwicklungspotenzial zur Verbesserung der personalisierten Tumorchirurgie.

Sections du résumé

BACKGROUND BACKGROUND

OBJECTIVE OBJECTIVE

To provide an overview on the applications of SRH in neurosurgery and transference of the technique to other surgical disciplines.

METHODS METHODS

Description of the technique and review of the current literature on SRH.

RESULTS RESULTS

The SRH technique was successfully used in multiple neuro-oncological tumor entities. Initial pilot projects showed the potential for analysis of extracranial tumors.

CONCLUSION CONCLUSIONS

The use of SRH provides a near real-time diagnosis with high diagnostic accuracy and provides further developmental potential to improve personalized tumor surgery.

ZUSAMMENFASSUNG UNASSIGNED

HINTERGRUND: Ein individualisiertes chirurgisches Vorgehen ist in der Hirntumorchirurgie zum Erreichen einer maximal sicheren Resektion essenziell. Die Radikalität der Resektion ist maßgeblich abhängig von der histologischen Diagnose. Die stimulierte Raman-Histologie (SRH), eine laserbasierte optische Bildgebung, bietet die Möglichkeit der Erhebung einer intraoperativen Diagnose in wenigen Minuten.

ZIEL DER ARBEIT UNASSIGNED

Überblick über die Anwendung von SRH in der Neurochirurgie und Übertragung der Technik auf weitere chirurgische Disziplinen.

METHODEN METHODS

Beschreibung der Technik und Zusammenfassung der aktuellen Literatur zu SRH.

ERGEBNISSE UNASSIGNED

SRH konnte erfolgreich bei multiplen neuroonkologischen Tumorentitäten angewendet werden. Erste Pilotprojekte zeigen Potenzial zur Analyse extrazerebraler Tumoren auf.

ZUSAMMENFASSUNG UNASSIGNED

SRH ermöglicht eine Echtzeitdiagnose mit hoher diagnostischer Genauigkeit und bietet weiteres Entwicklungspotenzial zur Verbesserung der personalisierten Tumorchirurgie.

Autres résumés

Type: Publisher (ger)

Identifiants

DOI: 10.1007/s00104-024-02038-5 PMID: 38334774

pubmed: 38334774

doi: 10.1007/s00104-024-02038-5

pii: 10.1007/s00104-024-02038-5

doi:

Types de publication

English Abstract Journal Article Review

Langues

ger

Sous-ensembles de citation

Pagination

274-279

Informations de copyright

Références

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