CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
09 Feb 2024
Historique:
medline: 9 2 2024
pubmed: 9 2 2024
entrez: 9 2 2024
Statut: ppublish

Résumé

Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact of DNA methylation loss on transcription has not been investigated. Here, we show that CDCA7 is critical for maintaining global DNA methylation levels across multiple tissues in vivo. A pathogenic

Identifiants

DOI: 10.1126/sciadv.adk3384 PMID: 38335290
pubmed: 38335290
doi: 10.1126/sciadv.adk3384
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadk3384

Auteurs

Maja Vukic (M)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0002-7555-7706

Jihed Chouaref (J)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.

Veronica Della Chiara (V)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0003-2307-7513

Serkan Dogan (S)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0001-6932-7165

Fallon Ratner (F)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0009-0001-2262-9382

Jenna Z M Hogenboom (JZM)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0009-0002-5392-8390

Trevor A Epp (TA)

Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
CZ-OPENSCREEN, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
ORCID: 0000-0003-2684-4247

Kallayanee Chawengsaksophak (K)

Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
ORCID: 0000-0001-9401-2122

Kelly K D Vonk (KKD)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0002-0726-8283

Cor Breukel (C)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0002-7735-9703

Yavuz Ariyurek (Y)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.

David San Leon Granado (D)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0001-8138-500X

Susan L Kloet (SL)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Leiden Genome Technology Center, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0001-9189-0640

Lucia Daxinger (L)

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0001-6557-6201

Classifications MeSH