Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare bone marrow disorder caused by acquired mutations in the phosphatidylinositol glycan class A gene, which lead to a partial or total loss of the cellular complement regulators CD55 and CD59.1 In addition to complement-mediated hemolysis and cytopenia, venous and arterial thromboses at multiple and/or unusual sites are a common complication and occur in up to 44% of patients in historic PNH cohorts.1 2.

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Déclaration de conflit d'intérêts

LB, TDF, FF, JF, LW, AB-H: no conflicts of interest. CB: Grants or contracts from any entity: Alexion Pharmaceuticals, Daiichi Sankyo. FL: Consulting fees: Daiichi Sankyo, Leo Pharma, Pfizer, Sanofi, Viatris; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Daiichi Sankyo, Leo Pharma, Pfizer, Sanofi, Viatris.