Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response.

Autonomic nervous system Desogestrel Heart rate variability Hypoventilation syndrome

Journal

Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633

Informations de publication

Date de publication:
09 Feb 2024
Historique:
received: 06 07 2023
accepted: 03 12 2023
medline: 10 2 2024
pubmed: 10 2 2024
entrez: 9 2 2024
Statut: epublish

Résumé

After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.Clinical Trials Identifier NCT01243697.

Identifiants

DOI: 10.1186/s12931-023-02625-w PMID: 38336689
pubmed: 38336689
doi: 10.1186/s12931-023-02625-w
pii: 10.1186/s12931-023-02625-w
doi:

Banques de données

ClinicalTrials.gov
['NCT01243697']

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

87

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Caroline Sevoz-Couche (C)

Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, 75013, Paris, France. caroline.sevoz-couche@sorbonne-universite.fr.

Maxime Patout (M)

Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, 75013, Paris, France.
Département R3S (Respiration, Réanimation, Réadaptation Respiratoire, Sommeil), Service des Pathologies du Sommeil, AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013, Paris, France.
Département R3S (Respiration, Réanimation, Réadaptation Respiratoire, Sommeil), Centre de Référence Constitutif Maladies Pulmonaires Rares de l'Adulte Orphalung, Hypoventilations Centrales, Syndrome d'Ondine, AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013, Paris, France.

Beny Charbit (B)

Faculté de Médecine, EA 3801, Université de Reims Champagne Ardenne, 51095, Reims, France.
Anesthesia, Critical Care and Pain Medicine Department, CHU Reims, Hôpital Robert Debré, 51092, Paris, France.

Thomas Similowski (T)

Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, 75013, Paris, France.
Département R3S (Respiration, Réanimation, Réadaptation Respiratoire, Sommeil), AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013, Paris, France.

Christian Straus (C)

Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, 75013, Paris, France.
Département R3S (Respiration, Réanimation, Réadaptation Respiratoire, Sommeil), Service d'Explorations Fonctionnelles de la Respiration, de l'Exercice et de la Dyspnée, AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013, Paris, France.

Classifications MeSH