Endogenous cannabinoids in the piriform cortex tune olfactory perception.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 Feb 2024
09 Feb 2024
Historique:
received:
11
07
2022
accepted:
17
01
2024
medline:
10
2
2024
pubmed:
10
2
2024
entrez:
9
2
2024
Statut:
epublish
Résumé
Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated by central neuronal circuits. In the sensory cortex, desynchronized network states associate with high signal-to-noise ratio stimulus-evoked responses and heightened perception. Cannabinoid-type-1-receptors (CB1Rs) - which influence network coordination in the hippocampus - are present in anterior piriform cortex (aPC), a sensory paleocortex supporting olfactory perception. Yet, how CB1Rs shape aPC network activity and affect odor perception is unknown. Using pharmacological manipulations coupled with multi-electrode recordings or fiber photometry in the aPC of freely moving male mice, we show that systemic CB1R blockade as well as local drug infusion increases the amplitude of gamma oscillations in aPC, while simultaneously reducing the occurrence of synchronized population events involving aPC excitatory neurons. In animals exposed to odor sources, blockade of CB1Rs reduces correlation among aPC excitatory units and lowers behavioral olfactory detection thresholds. These results suggest that endogenous endocannabinoid signaling promotes synchronized population events and dampen gamma oscillations in the aPC which results in a reduced sensitivity to external sensory inputs.
Identifiants
pubmed: 38336844
doi: 10.1038/s41467-024-45161-x
pii: 10.1038/s41467-024-45161-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1230Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : ERC-StG- 851560
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : ERC-2017-AdG-786467
Organisme : Fondation pour la Recherche Médicale (Foundation for Medical Research in France)
ID : FSER202112014572
Organisme : Fondation pour la Recherche Médicale (Foundation for Medical Research in France)
ID : FDT20170436845
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-10-INBS-04
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-16-CE37-0010
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-16-CE37-0010
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-16-CE37-0010
Informations de copyright
© 2024. The Author(s).
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