Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 Feb 2024
09 Feb 2024
Historique:
received:
21
12
2022
accepted:
31
01
2024
medline:
10
2
2024
pubmed:
10
2
2024
entrez:
9
2
2024
Statut:
epublish
Résumé
The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer's Disease is commonly preceded by a prodromal period. Here, we report the presence of large Aβ aggregates in plasma from patients with mild cognitive impairment (n = 38). The aggregates are associated with low level Alzheimer's Disease-like brain pathology as observed by
Identifiants
pubmed: 38336934
doi: 10.1038/s41467-024-45627-y
pii: 10.1038/s41467-024-45627-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224Subventions
Organisme : Aarhus Universitets Forskningsfond (Aarhus University Research Foundation)
ID : AUFF-E-2015-FLS-9-6
Organisme : Aarhus Universitets Forskningsfond (Aarhus University Research Foundation)
ID : AU IDEAS 2013
Organisme : Aarhus Universitets Forskningsfond (Aarhus University Research Foundation)
ID : AUFF-E-2015-FLS-9-6
Organisme : Aarhus Universitets Forskningsfond (Aarhus University Research Foundation)
ID : AU IDEAS 2013
Organisme : Aarhus Universitets Forskningsfond (Aarhus University Research Foundation)
ID : AU IDEAS 2013
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF19OC0058516
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF19OC0058516
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF21OC0071574
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R380-2021-1326
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R380-2021-1326
Organisme : Det Frie Forskningsråd (Danish Council for Independent Research)
ID : 2030-00002B
Organisme : Det Frie Forskningsråd (Danish Council for Independent Research)
ID : 3101-00104B
Organisme : Det Frie Forskningsråd (Danish Council for Independent Research)
ID : 2030-00002B
Organisme : Det Frie Forskningsråd (Danish Council for Independent Research)
ID : 4004-00305
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 European Institute of Innovation and Technology (H2020 The European Institute of Innovation and Technology)
ID : 820636
Organisme : Danmarks Grundforskningsfond (Danish National Research Foundation)
ID : DNRF135
Informations de copyright
© 2024. The Author(s).
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