Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis.

Animals Mice Proteostasis Transcription Factors / metabolism Muscle, Skeletal / metabolism Chromatin Immunoprecipitation

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
Feb 2024
Historique:
received: 02 04 2022
accepted: 09 01 2024
medline: 28 2 2024
pubmed: 10 2 2024
entrez: 10 2 2024
Statut: ppublish

Résumé

Skeletal muscle is dynamically controlled by the balance of protein synthesis and degradation. Here we discover an unexpected function for the transcriptional repressor B cell lymphoma 6 (BCL6) in muscle proteostasis and strength in mice. Skeletal muscle-specific Bcl6 ablation in utero or in adult mice results in over 30% decreased muscle mass and force production due to reduced protein synthesis and increased autophagy, while it promotes a shift to a slower myosin heavy chain fibre profile. Ribosome profiling reveals reduced overall translation efficiency in Bcl6-ablated muscles. Mechanistically, tandem chromatin immunoprecipitation, transcriptomic and translational analyses identify direct BCL6 repression of eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1) and activation of insulin-like growth factor 1 (Igf1) and androgen receptor (Ar). Together, these results uncover a bifunctional role for BCL6 in the transcriptional and translational control of muscle proteostasis.

Identifiants

DOI: 10.1038/s42255-024-00983-3 PMID: 38337096 PMC: PMC10949880
pubmed: 38337096
doi: 10.1038/s42255-024-00983-3
pii: 10.1038/s42255-024-00983-3
pmc: PMC10949880
mid: NIHMS1966396
doi:

Substances chimiques

Transcription Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

304-322

Subventions

Organisme : NHLBI NIH HHS
ID : R56 HL158531
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108987
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL061322
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS047726
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008061
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG078174
Pays : United States
Organisme : BLRD VA
ID : I01 BX004898
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL166356
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK130908
Pays : United States

Informations de copyright

© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Auteurs

Krithika Ramachandran (K)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Christopher R Futtner (CR)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jesse Brown VA Medical Center, Chicago, IL, USA.

Meredith A Sommars (MA)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Mattia Quattrocelli (M)

Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Division of Molecular Cardiovascular Biology, Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
ORCID: 0000-0001-7011-1740

Yasuhiro Omura (Y)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jesse Brown VA Medical Center, Chicago, IL, USA.

Ellen Fruzyna (E)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0002-6902-2078

Janice C Wang (JC)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0001-8669-9681

Nathan J Waldeck (NJ)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Madhavi D Senagolage (MD)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Carmen G Telles (CG)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Alexis R Demonbreun (AR)

Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Erin Prendergast (E)

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.

Nicola Lai (N)

Department of Mechanical, Chemical, and Materials Engineering, University of Cagliari, Cagliari, Italy.
ORCID: 0000-0002-3436-289X

Daniel Arango (D)

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0001-9523-830X

Ilya R Bederman (IR)

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
ORCID: 0000-0002-1909-5746

Elizabeth M McNally (EM)

Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0002-1221-719X

Grant D Barish (GD)

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. grant.barish@northwestern.edu.
Jesse Brown VA Medical Center, Chicago, IL, USA. grant.barish@northwestern.edu.
ORCID: 0000-0001-8753-0546

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Transcriptional programming of translation by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcriptional programming of translation by...
questionsmedicales.fr › Métabolisme › Homéostasie protéique › Transcriptional programming of translation by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Transcriptional programming of translation by...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Transcriptional programming of translation by...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunoprécipitation › Immunoprécipitation de la chromatine › Transcriptional programming of translation by...