Cumulative Deleterious Effects of Tetrahydrocannabinoid (THC) and Ethanol on Mitochondrial Respiration and Reactive Oxygen Species Production Are Enhanced in Old Isolated Cardiac Mitochondria.

aging alcohol cannabis ethanol heart marijuana mitochondria oxidative stress tetrahydrocannabinoid

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Feb 2024
Historique:
received: 15 12 2023
revised: 24 01 2024
accepted: 31 01 2024
medline: 10 2 2024
pubmed: 10 2 2024
entrez: 10 2 2024
Statut: epublish

Résumé

Delta 9 tetrahydrocannabinol (THC), the main component of cannabis, has adverse effects on the cardiovascular system, but whether concomitant ethanol (EtOH) and aging modulate its toxicity is unknown. We investigated dose responses of THC and its vehicle, EtOH, on mitochondrial respiration and reactive oxygen production in both young and old rat cardiac mitochondria (12 and 90 weeks). THC dose-dependently impaired mitochondrial respiration in both groups, and such impairment was enhanced in aged rats (-97.5 ± 1.4% vs. -75.6 ± 4.0% at 2 × 10

Identifiants

DOI: 10.3390/ijms25031835 PMID: 38339113
pubmed: 38339113
pii: ijms25031835
doi: 10.3390/ijms25031835
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Anne-Laure Charles (AL)

Biomedicine Research Center of Strasbourg (CRBS), UR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", University of Strasbourg, 67000 Strasbourg, France.
Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
ORCID: 0000-0003-3557-2642

Anne Charloux (A)

Biomedicine Research Center of Strasbourg (CRBS), UR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", University of Strasbourg, 67000 Strasbourg, France.
Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
Department of Physiology and Functional Explorations, University Hospital of Strasbourg, 67091 Strasbourg, France.

Thomas Vogel (T)

Biomedicine Research Center of Strasbourg (CRBS), UR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", University of Strasbourg, 67000 Strasbourg, France.
Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
Geriatrics Department, University Hospital of Strasbourg, 67091 Strasbourg, France.

Jean-Sébastien Raul (JS)

Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
Toxicology Laboratory, Institute of Legal Medicine, Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.

Michel Kindo (M)

Biomedicine Research Center of Strasbourg (CRBS), UR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", University of Strasbourg, 67000 Strasbourg, France.
Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
Cardiovascular Surgery Department, University Hospital of Strasbourg, 67091 Strasbourg, France.
ORCID: 0000-0001-8884-4395

Valérie Wolff (V)

Biomedicine Research Center of Strasbourg (CRBS), UR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", University of Strasbourg, 67000 Strasbourg, France.
Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
Neuro-Vascular Department, University Hospital of Strasbourg, 67098 Strasbourg, France.

Bernard Geny (B)

Biomedicine Research Center of Strasbourg (CRBS), UR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", University of Strasbourg, 67000 Strasbourg, France.
Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France.
Department of Physiology and Functional Explorations, University Hospital of Strasbourg, 67091 Strasbourg, France.

Classifications MeSH