The dark sides of the GPCR tree - research progress on understudied GPCRs.
Frizzleds
G protein-coupled receptors
adhesion GPCRs
odorant receptors
orphan receptors
taste receptors
understudied GPCRs
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
10 Feb 2024
10 Feb 2024
Historique:
revised:
24
11
2023
received:
25
08
2023
accepted:
08
01
2024
medline:
10
2
2024
pubmed:
10
2
2024
entrez:
10
2
2024
Statut:
aheadofprint
Résumé
A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further. Open questions on these GPCRs span diverse topics such as deorphanisation, the development of tool compounds and tools for studying these GPCRs, as well as understanding basic signalling mechanisms. This review gives an overview of the current state of knowledge for each of the diverse subfamilies of understudied receptors regarding their physiological relevance, molecular mechanisms, endogenous ligands and pharmacological tools. Furthermore, it identifies some of the largest knowledge gaps that should be addressed in the foreseeable future and lists some general strategies that might be helpful in this process.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cancerfonden
ID : 20 1102 PjF
Organisme : Deutsche Forschungsgemeinschaft
ID : 470002134
Organisme : Deutsche Forschungsgemeinschaft
ID : PI 1672/3-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1423
Organisme : HORIZON EUROPE Marie Sklodowska-Curie Actions
ID : 101062195
Organisme : Leibniz Best Minds Programme for Women Professors
Organisme : Novo Nordisk Fonden
ID : NNF22OC0078104
Organisme : Vetenskapsrådet
ID : 2019-01190
Informations de copyright
© 2024 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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